Evaluation of fluoride-induced oxidative stress in rat brain: a multigeneration study

Biological Trace Element Research
Piler Mahaboob BashaShabana Begum

Abstract

Multigenerational evaluation was made in rats on exposure to high fluoride (100 and 200 ppm) to assess neurotoxic potential of fluoride in discrete areas of the brain in terms of lipid peroxidation and the activity of antioxidant enzyme system. The rats were given fluoride through drinking water (100 and 200 ppm) and maintained subsequently for three generations. Fluoride treatment significantly increased the lipid peroxidation and decreased the activity of antioxidant enzymes viz, catalase, superoxide dismutase, glutathione peroxidase, glutathione S-transferase, and glutathione level in first-generation rats and these alterations were more pronounced in the subsequent second and third-generation rats in both the doses tested. Decreased feed and water consumption, litter size and organ (brain) somatic index, marginal drop in body growth rate and mortality were observed in all three generations. Decreased antioxidant enzyme activity and increased malondialdehyde levels found in the present study might be related to oxidative damage that occurs variably in discrete regions of the brain. Results of this study can be taken as an index of neurotoxicity in rats exposed to water fluoridation over several generations.

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Citations

Sep 21, 2013·Toxicology Letters·Ekambaram PerumalLakshmikanthan Panneerselvam
Jun 6, 2013·Oxidative Medicine and Cellular Longevity·Paula Mochidome YamagutiJosé Nicolau
Apr 30, 2015·Physiology & Behavior·Mariana BartosAlejandra Minetti
Jun 4, 2013·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Olusegun L AdebayoGbenga A Adenuga
Sep 24, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Rajkiran Reddy Banala, Pratap Reddy Karnati
Feb 20, 2020·Critical Reviews in Toxicology·N I Agalakova, O V Nadei
Sep 1, 2020·Biological Trace Element Research·Yugandhar P ReddyVarun Kumar Sharma
Dec 31, 2019·Journal of Toxicology·Manuel Sánchez-GutiérrezJeannett Alejandra Izquierdo-Vega

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