[Evaluation of folate substitution in women with epilepsy. Determination of erythrocyte folic acid concentrations].

Der Nervenarzt
J BauerB Stoffel-Wagner

Abstract

Insufficient maternal folate concentrations appear to be a fetal risk factor for neural tube defects (NTD). Erythrocyte folate concentrations are widely accepted as an indicator of tissue folate storage. We retrospectively evaluated erythrocyte folate concentrations to examine if a recommended daily dosage of 5 mg folic acid is sufficient to balance the impact of antiepileptic drugs (AED) on folate metabolism in women with epilepsy. Data of 48 women (mean age 30.3 years) with idiopathic epilepsy with generalized seizures (n=12) or symptomatic epilepsy with focal seizures (n=36) were available, 43 women submitted to further analysis and 30 women received AED monotherapy. Duration of folic acid supplementation varied between 0.5 and 12 months. The daily dosage of folic acid ranged from 0.4 to 15 mg and 32 women received 5 mg/day. Erythrocyte folate concentrations ranged from 282 to 1596 ng/ml (mean 780 ng/ml). In 29 out of the 32 women (90.6%) on 5 mg folic acid per day, red cell folate was ≥400 ng/ml. In previous studies the risk for NTD was estimated to be 0.8‰ if red cell folate was ≥400 ng/ml. Our results suggest that 5 mg/day folic acid as preconception supplementation in women with epilepsy is effective to balance the impac...Continue Reading

References

Dec 24, 1992·The New England Journal of Medicine·A E Czeizel, I Dudás
Dec 6, 1995·JAMA : the Journal of the American Medical Association·L E DalyJ M Scott
Nov 11, 2003·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·R Douglas WilsonUNKNOWN Genetics Committee and Executive and Council of the Society of Obstetricians and Gynaecologists of Canada
Nov 15, 2007·BJOG : an International Journal of Obstetrics and Gynaecology·D KjaerJ Olsen

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Citations

Feb 22, 2012·Der Nervenarzt·S Weil, G Luef
Apr 9, 2013·Clinical Obstetrics and Gynecology·Manijeh Kamyar, Michael Varner

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