Evaluation of food-drug interaction of guava leaf tea

Phytotherapy Research : PTR
Kimiyuki KanekoMasaharu Onoue

Abstract

Guava leaf tea (GLT) contains guava leaf polyphenol (Gvpp), which regulates the absorption of dietary carbohydrate from the intestines. Borderline diabetics, who are at high risk of development of diabetes, take GLT to suppress a rapid increase of blood sugar level after meals. However, patients with diabetes in whom diabetic drugs or warfarin as a blood thinner are prescribed also take GLT with the expectation of glycemic control. Therefore, we studied whether GLT had potential for inhibition or induction of cytochrome P450 (CYP) and an influence on the action of warfarin. Extract of guava leaf (GvEx) consists of carbohydrate and polyphenols, which are Gvpp, quercetin, and ellagic acid. These polyphenols, but not GvEx, showed a certain level of inhibition of human-cDNA-expressed CYPs. In a comparison of GLT and grapefruit juice, GLT showed weaker inhibition of CYP activities and of midazolam 1'-hydroxylation than grapefruit juice. Furthermore, neither liver weight nor CYP3A expression in the liver was changed in rats that received GvEx for 90 days compared with the control group. When rats were concomitantly treated with GLT and warfarin, the prolongation of clotting time of blood by warfarin was not influenced. These data sug...Continue Reading

References

Nov 24, 1999·British Journal of Anaesthesia·Y OdaA Asada
Jun 22, 2000·Archives of Biochemistry and Biophysics·W TassaneeyakulY Yamazoe
Aug 9, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Yuan Hua WenVsevolod E Kostrubsky
Apr 16, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Judy L Raucy
Dec 18, 2003·European Journal of Clinical Nutrition·A Dahan, H Altman
May 19, 2004·Biochemical and Biophysical Research Communications·Cédric GaudineauKarine Auclair
Dec 17, 2004·Journal of Clinical Pharmacology·Robert L WalskyR Scott Obach
May 25, 2005·Archives of Internal Medicine·Anne M HolbrookPhilip S Wells
Sep 24, 2005·Basic & Clinical Pharmacology & Toxicology·Lauri I KajosaariJanne T Backman
Apr 14, 2006·Expert Opinion on Drug Safety·Edith A NutescuPatricia West
Jan 12, 2007·Basic & Clinical Pharmacology & Toxicology·Bent H HellumOdd Georg Nilsen
Feb 9, 2007·Journal of Pharmacological Sciences·Kazuhiro MatsudaHajime Yasuhara
Sep 19, 2007·Journal of Nutritional Science and Vitaminology·Truong Tuyet MaiNguyen Van Chuyen
Oct 9, 2007·Clinical Therapeutics·Christine H PaengCynthia A Jackevicius
Feb 19, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H LeungT Y K Chan
Mar 28, 2008·Pharmacotherapy·Lori B HornsbyAmy R Donaldson
Apr 19, 2008·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Y DengS-F Zhou
May 30, 2008·Journal of Medicinal Chemistry·Elena Lo PiparoChieh Jason Chou
Nov 4, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yuka KimuraTsutomu Hatano

❮ Previous
Next ❯

Citations

May 8, 2016·Journal of Ethnopharmacology·Ashutosh SharmaMaría Luisa Villarreal
Apr 27, 2017·International Journal of Molecular Sciences·Elixabet Díaz-de-CerioAntonio Segura-Carretero
Jan 2, 2016·Pharmacological Reviews·Janne T BackmanPertti J Neuvonen
Apr 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·You LuoZhenqiang Wu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved