Evaluation of formulation properties and skin penetration in the same additive-containing formulation

Results in Pharma Sciences
Yutaka InoueIkuo Kanamoto

Abstract

The aim of this study is to examine the physicochemical properties of the external preparation, the effect on the skin permeability and the human senses. Miconazole nitrate cream formulation (MCZ-A: bland name and MCZ-B, -C, -D: generics) to measure the physicochemical properties, was performed by the skin permeation test and human sensory test. The flattening, viscoelasticity, and water content of each cream were measured and each cream was subjected to near-infrared (NIR) absorption spectroscopy and human sensory testing. The yield value was calculated based on measured flattening and was 734.8 dynes/cm(2) for MCZ-A, 1198.9 dynes/cm(2) for MCZ-B, 461.3 dynes/cm(2) for MCZ-C and 3112.3 dynes/cm(2) for MCZ-D. Measurement of viscoelasticity and viscosity revealed that MCZ-C had a smaller tanδ than the other 3 creams at 25 °C. NIR absorption spectroscopy revealed that MCZ-A had the highest absorption peak due to hydroxyl groups, followed by MCZ-C, -B, and then -D. Measurement of water content revealed that MCZ-A had a water content of 65.9%, MCZ-B, -C, and -D had a water content of around 56.3%. Human sensory testing revealed differences between MCZ-A and MCZ-C and between MCZ-B and MCZ-D in terms of spreadability and feel. These...Continue Reading

Citations

Mar 10, 2017·Drug Development and Industrial Pharmacy·Tamás VighZsombor K Nagy
Aug 30, 2018·Journal of Pharmaceutics·Yutaka InoueIkuo Kanamoto
Aug 16, 2019·Journal of Oleo Science·Asami MiyajimaRyo Hyodo
Mar 23, 2018·Journal of Palliative Medicine·Minako TsurutaYosei Kawamata

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