PMID: 2091921Jan 1, 1990Paper

Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: confirmation of earlier results with 41 additional chemicals

Environmental and Molecular Mutagenesis
E ZeigerR Tennant

Abstract

The effectiveness of four in vitro short-term tests (STT) for genetic toxicity, induction of mutations in Salmonella (SAL) and mouse lymphoma L5178Y cells (MLA), and induction of sister chromatid exchanges (SCE) and chromosome aberrations (ABS) in Chinese hamster ovary cells that are used for predicting rodent carcinogenicity were examined. The in vitro results were compared with the results from 41 rodent carcinogenicity studies performed by the National Toxicology Program. The predictive values of, and interrelationships among, the STT for these 41 chemicals were similar to those previously reported for 73 chemicals and confirm those earlier results [Tennant RW, Margolin BH, Shelby MD, Zeiger E, Haseman JK, Spalding J, Caspary W, Resnick M, Stasiewicz S, Anderson B, Minor R (1987): Science 236:933-941]. Because of this similarity among the two datasets, the chemicals were combined into a single dataset of 114. The results with 114 chemicals show that SAL had the lowest sensitivity (.48) and the highest specificity (.91), whereas MLA had the highest sensitivity (.72) and the lowest specificity (.40). The concordances of the test results with rodent carcinogenicity were .66, .61, .59, and .59, for SAL, ABS, SCE, and MLA, respec...Continue Reading

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Citations

Feb 18, 2011·Archives of Toxicology·Giovanni BrambillaAntonietta Martelli
Nov 1, 1993·Mutation Research·E Zeiger
May 1, 1995·Mutation Research·Y LeeH S Rosenkranz
Aug 17, 1996·Mutation Research·M A JacksonM D Waters
Oct 1, 1992·Mutation Research·W L YangH S Rosenkranz
Apr 1, 1993·Mutation Research·H S Rosenkranz, G Klopman
Jun 1, 1994·Mutation Research·D GatehouseS Venitt
Dec 6, 2012·Cancer Letters·Gabriele Ludewig, Larry W Robertson
Dec 13, 2000·Mutation Research·K Mortelmans, E Zeiger
Dec 13, 2000·Mutation Research·J T MacGregorL Müller
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Apr 17, 2002·Toxicology·Robert R Young
Jul 10, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yoshitsugu Kajiwara, Syozo Ajimi
Nov 6, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Cristina AndreoliAlfredo Nunziata
Mar 10, 2000·Mutation Research·S G GrantH S Rosenkranz
Jul 1, 1995·Journal of Toxicology and Environmental Health·R Benigni
Dec 1, 1991·Environmental Health Perspectives·N LoprienoM Tesoro

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