Evaluation of FSH, LH, testosterone levels and semen parameters in male boron workers under extreme exposure conditions

Archives of Toxicology
Yalçin DuyduHermann M Bolt

Abstract

Boric acid and sodium borates are currently classified in the EU-CLP regulation as "toxic to reproduction" under "Category 1B", with hazard statement of H360FD. However, so far field studies on male reproduction in China and in Turkey could not confirm such boron-associated toxic effects. As validation by another independent study is still required, the present study has investigated possible boron-associated effects on male reproduction in workers (n = 212) under different boron exposure conditions. The mean daily boron exposure (DBE) and blood boron concentration of workers in the extreme exposure group (n = 98) were 47.17 ± 17.47 (7.95-106.8) mg B/day and 570.6 ± 160.1 (402.6-1100) ng B/g blood, respectively. Nevertheless, boron-associated adverse effects on semen parameters, as well as on FSH, LH and total testosterone levels were not seen, even within the extreme exposure group. With this study, a total body of evidence has accumulated that allows to conclude that male reproductive effects are not relevant to humans, under any feasible and realistic conditions of exposure to inorganic boron compounds.

References

Feb 7, 1998·Reproductive Toxicology·P A FailJ J Heindel
Jan 10, 2008·Journal of Occupational and Environmental Hygiene·Xiaoru XingWendie Robbins
Dec 8, 2009·Reproductive Toxicology·Wendie A RobbinsLiu Ping
Aug 13, 2011·Archives of Toxicology·Yalçin DuyduHermann M Bolt
May 12, 2012·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Nurşen BaşaranHermann M Bolt
Jun 5, 2012·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Yalçin DuyduHermann M Bolt
Jun 13, 2012·Journal of Toxicology and Environmental Health. Part a·Hermann M BoltYalçın Duydu
Jun 12, 2017·Archives of Toxicology·Hermann M BoltKlaus Golka
Jun 28, 2018·Archives of Toxicology·Yalçın DuyduHermann M Bolt

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Citations

Mar 15, 2020·Archives of Toxicology·Hermann M BoltYalçin Duydu

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