Evaluation of fully automated a priori MCO treatment planning in VMAT for head-and-neck cancer.

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
Marie-Claude BistonVincent Grégoire

Abstract

Automated planning techniques aim to reduce manual planning time and inter-operator variability without compromising the plan quality which is particularly challenging for head-and-neck (HN) cancer radiotherapy. The objective of this study was to evaluate the performance of an a priori-multicriteria plan optimization algorithm on a cohort of HN patients. A total of 14 nasopharyngeal carcinoma (upper-HN) and 14 "middle-lower indications" (lower-HN) previously treated in our institution were enrolled in this study. Automatically generated plans (autoVMAT) were compared to manual VMAT or Helical Tomotherapy planning (manVMAT-HT) by assessing differences in dose delivered to targets and organs at risk (OARs), calculating plan quality indexes (PQIs) and performing blinded comparisons by clinicians. Quality control of the plans and measurements of the delivery times were also performed. For the 14 lower-HN patients, with equivalent planning target volume (PTV) dosimetric criteria and dose homogeneity, significant decrease in the mean doses to the oral cavity, esophagus, trachea and larynx were observed for autoVMAT compared to manVMAT-HT. Regarding the 14 upper-HN cases, the PTV coverage was generally significantly superior for autoV...Continue Reading

References

Mar 17, 2010·Medical Physics·Andrea L McNivenThomas G Purdie
Feb 9, 2011·International Journal of Radiation Oncology, Biology, Physics·David L CraftThomas R Bortfeld
Jun 5, 2012·International Journal of Radiation Oncology, Biology, Physics·Peter W J VoetBen J M Heijmen
Nov 5, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Vincent GrégoireBenoit Lengele
Feb 18, 2014·International Journal of Radiation Oncology, Biology, Physics·Peter W J VoetBen J M Heijmen
Jul 30, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Núria JornetJordi Sáez
Feb 15, 2015·International Journal of Radiation Oncology, Biology, Physics·Jim P TolWilko F A R Verbakel
Mar 3, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Abdul Wahab M SharfoBen J M Heijmen
Aug 19, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Charlotte L BrouwerJohannes A Langendijk
Nov 12, 2015·Radiation Oncology·Jerome KrayenbuehlMatthias Guckenberger
Feb 20, 2016·Journal of Applied Clinical Medical Physics·Irene HazellCarsten Brink
Mar 21, 2017·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Giuseppe Della GalaSteven F Petit
Apr 30, 2017·Radiation Oncology·A FogliataL Cozzi
Jun 28, 2017·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Stefan SpeerChristoph Bert
Aug 5, 2017·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·J M A M KustersJ H A M Kaanders
Sep 19, 2016·Clinical and Translational Radiation Oncology·Christian Rønn HansenCarsten Brink
Jul 5, 2018·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ben HeijmenSebastiaan Breedveld
Aug 4, 2018·The British Journal of Radiology·Mohammad HusseinAndrew Nisbet
Nov 19, 2018·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tomas M JanssenSteven F Petit

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