Evaluation of functional connectivity in subdivisions of the thalamus in schizophrenia

The British Journal of Psychiatry : the Journal of Mental Science
Jinnan GongDezhong Yao

Abstract

Previous studies in schizophrenia revealed abnormalities in the cortico-cerebellar-thalamo-cortical circuit (CCTCC) pathway, suggesting the necessity for defining thalamic subdivisions in understanding alterations of brain connectivity.AimsTo parcellate the thalamus into several subdivisions using a data-driven method, and to evaluate the role of each subdivision in the alterations of CCTCC functional connectivity in patients with schizophrenia. There were 54 patients with schizophrenia and 42 healthy controls included in this study. First, the thalamic structural and functional connections computed, based on diffusion magnetic resonance imaging (MRI, white matter tractography) and resting-state functional MRI, were clustered to parcellate thalamus. Next, functional connectivity of each thalamus subdivision was investigated, and the alterations in thalamic functional connectivity for patients with schizophrenia were inspected. Based on the data-driven parcellation method, six thalamic subdivisions were defined. Loss of connectivity was observed between several thalamic subdivisions (superior-anterior, ventromedial and dorsolateral part of the thalamus) and the sensorimotor system, anterior cingulate cortex and cerebellum in pat...Continue Reading

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Citations

Jul 24, 2020·Brain Imaging and Behavior·Hui HeDezhong Yao
Oct 6, 2020·BioMed Research International·Yutong YaoCheng Luo
Apr 19, 2020·Brain Imaging and Behavior·Chuanjun ZhuoXueqin Song
Oct 2, 2019·Frontiers in Neurology·Stéphane PotvinOvidiu Lungu
Jul 6, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Valentina ManciniStephan Eliez

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