Evaluation of functional nerve recovery after reconstruction with a poly (DL-lactide-epsilon-caprolactone) nerve guide, filled with modified denatured muscle tissue

Microsurgery
M F MeekP H Robinson

Abstract

The aim of this study was to compare the speed of functional nerve recovery after reconstruction with a biodegradable p(DLLA-epsilon-CL) nerve guide, as filled with either modified denatured muscle tissue (MDMT) or phosphate-buffered saline (PBS). To evaluate both motor and sensory nerve recovery, walking-track analysis and electrostimulation tests were carried out after implantation periods, ranging from 3-15 weeks. Functional nerve recovery after reconstruction of a 15-mm nerve gap, with a biodegradable p(DLLA-epsilon-CL) nerve guide filled with modified denatured muscle tissue, was slightly faster, compared with nerve reconstruction of a 10-mm gap with a biodegradable p(DLLA-epsilon-CL) nerve guide filled with PBS. We conclude that our experiments have demonstrated that the use of MDMT increases the speed of recovery after reconstruction of a nerve gap with a p(DLLA-epsilon-CL) biodegradable nerve guide. Furthermore, the use of MDMT might open perspectives for repair of longer nerve gaps.

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Citations

Jun 9, 2004·Journal of Neuroscience Methods·Marcel F MeekAlbert Gramsbergen
Dec 31, 2003·Biomaterials·J IJkema-PaassenM F Meek
Jan 10, 2009·Journal of Materials Science. Materials in Medicine·Mingzhu Sun, Sandra Downes
Jul 21, 2005·Microsurgery·M F MeekP H Robinson
Sep 3, 2010·The Journal of Hand Surgery·Ignazio MarcoccioVigasio Adolfo
Dec 10, 2008·Neurosurgery Clinics of North America·Godard C W de RuiterMartijn J A Malessy
Oct 22, 2008·Biomaterials·Olivier AlluinPatrick Decherchi
Aug 10, 2005·Journal of Biomedical Materials Research. Part a·Jie CaiGeorge M Smith
May 21, 2008·Journal of Biomedical Materials Research. Part a·Minal PatelPamela VandeVord
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Dec 8, 2009·Journal of Biomedical Materials Research. Part a·M SunS Downes
May 14, 2014·Biomaterials·Xiaosong GuDavid F Williams
Jun 13, 2003·Annals of Plastic Surgery·M F Meek, J Henk Coert
Mar 6, 2003·Plastic and Reconstructive Surgery·Marcel F Meek, Jean-Philipe A Nicolai
Oct 20, 2000·Plastic and Reconstructive Surgery·M F MeekJ F van der Werff
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Jan 25, 2003·Annals of Plastic Surgery·M F Meek, A Gramsbergen
Jul 6, 2019·ACS Chemical Neuroscience·Shadi HoushyarRobert Shanks

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