Evaluation of functional recovery of recurrent laryngeal nerve using transoral laryngeal bipolar electromyography: a rat model

The Annals of Otology, Rhinology, and Laryngology
Belachew TessemaSteven D Schaefer

Abstract

We developed a standardized method of minimally invasive transoral laryngeal (ToL) bipolar electromyography (EMG) for evaluation of recurrent laryngeal nerve (RLN) recovery after a controlled crush injury in a rat model. Ten 200- to 250-g Sprague-Dawley rats underwent a controlled crush injury to the left RLN performed with 60 seconds of use of a calibrated aneurysm clamp with a closing force of 0.61 N. Serial ToL bipolar EMG was performed on adductor muscles and the posterior criocoarytenoid muscle during spontaneous vocal fold motion under anesthesia. Each animal underwent ToL EMG immediately after surgery and 1, 3, and 6 weeks after surgery. The EMG signals showed normal motor unit potentials and recruitment patterns 3 weeks after crush injury. Endoscopic evaluation of vocal fold mobility yielded consistently normal findings 6 weeks after crush injury. We have developed a standardized method of crush injury to the rat RLN model and a minimally invasive transoral bipolar spontaneous EMG technique to serially evaluate and follow nerve injury and recovery in rats. This model is intended to simulate intraoperative RLN injury, to elucidate the electrophysiological events that occur during nerve recovery, and to form the basis for...Continue Reading

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Citations

Mar 1, 2013·Journal of Anatomy·Ignacio Hernández-MoratoArán Pascual-Font
Jul 3, 2013·The Laryngoscope·Robbi A KupferNorman D Hogikyan
Jan 25, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ignacio Hernández-MoratoArán Pascual-Font
Apr 10, 2016·The Laryngoscope·Ignacio Hernandez-MoratoMichael J Pitman
Sep 16, 2014·The Laryngoscope·Ignacio Hernandez-MoratoMichael J Pitman
Sep 14, 2014·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Paulos Y MengsteabSang Jun Kim
Jul 17, 2016·Neuroscience·Ignacio Hernandez-MoratoMichael J Pitman
Mar 12, 2013·The Annals of Otology, Rhinology, and Laryngology·Yoshihiko KumaiEiji Yumoto
May 5, 2016·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Niv MorLucian Sulica
May 24, 2013·The Annals of Otology, Rhinology, and Laryngology·Michael J PitmanSansar Sharma
Jan 10, 2012·The Annals of Otology, Rhinology, and Laryngology·Philip WeissbrodSteven D Schaefer
Jun 9, 2009·The Laryngoscope·Belachew TessemaSteven D Schaefer
Feb 28, 2019·The Laryngoscope·Ignacio Hernandez-MoratoMichael J Pitman
Aug 2, 2013·Restorative Neurology and Neuroscience·Gina N MonacoEileen M Foecking
Sep 15, 2009·The Annals of Otology, Rhinology, and Laryngology·Wen XuErzhong Fan

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