Evaluation of gastrointestinal permeability and mucosal absorptive capacity in dogs with chronic enteropathy

American Journal of Veterinary Research
K AllenspachF Gaschen

Abstract

To assess intestinal mucosal function by measuring permeability and absorptive capacity in dogs with chronic enteropathy (CE) before and after treatment and to determine whether those variables were correlated with clinical disease activity or histologic scoring of intestinal biopsy specimens. 29 dogs with CE. Dogs were designated as having dietresponsive CE or CE requiring glucorticoid treatment. Severity of clinical signs was assessed by calculating the canine inflammatory bowel disease activity index (CIBDAI). Histologic severity of intestinal infiltration was assessed before and after 4 weeks of treatment in the diet-responsive group and before and after 10 weeks of treatment in the glucocorticoid group. Gastrointestinal permeability and mucosal absorptive capacity were assessed by use of intragastric administration of a solution containing lactulose, rhamnose, xylose, 3-O-methylglucose, and sucrose. Urine was collected 6 hours after administration of the sugar solution to determine urinary lactulose-to-rhamnose (L:R), xylose-to-methylglucose (X:M), and sucrose-to-methylglucose (S:M) ratios. Median CIBDAI scores decreased significantly in both groups of dogs after treatment. However, the median histologic grade of intestina...Continue Reading

References

Jul 1, 1995·The Journal of Small Animal Practice·H C RutgersF J Proud
Sep 1, 1996·The Journal of Small Animal Practice·H C RutgersR H Fensome
Aug 8, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·S H SørensenR M Batt
Oct 13, 1998·Research in Veterinary Science·O A GardenR M Batt
Aug 24, 2001·Journal of the American Veterinary Medical Association·M D WillardB R Weeks
Jun 14, 2002·American Journal of Veterinary Research·Jörg M SteinerErik M Moeller
Dec 6, 2002·Journal of Veterinary Internal Medicine·Elizabeth M StreeterLisa M Freeman
Feb 5, 2003·Journal of Veterinary Internal Medicine·A J GermanM J Day
May 31, 2003·Journal of Veterinary Internal Medicine·Albert E JergensRichard Evans
Apr 3, 2004·Journal of Veterinary Internal Medicine·Rafael FriasElias Westermarck
Jul 23, 2004·The Journal of Small Animal Practice·M CravenM L Chandler
Nov 10, 2004·Journal of the American Animal Hospital Association·Albert E Jergens

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Citations

Apr 9, 2009·Veterinary Clinical Pathology·Stefanie KlennerThomas Spillmann
May 3, 2011·Polish Journal of Veterinary Sciences·K MalewskaM Kander
May 21, 2011·Topics in Companion Animal Medicine·Olivier Dossin
Feb 22, 2011·Journal of Comparative Pathology·S Van der HeydenR Ducatelle
Aug 27, 2015·Journal of Veterinary Internal Medicine·H TitmarshR J Mellanby
May 15, 2013·Journal of Veterinary Internal Medicine·D WalkerO A Garden
Aug 7, 2007·The Journal of Veterinary Medical Science·Saku KobayashiHajime Tsujimoto
Mar 31, 2016·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Candice BaileyBeth A Valentine
Jun 28, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Alison E RidyardHugh R P Miller
Jul 14, 2017·Journal of Veterinary Internal Medicine·M VolkmannB Kohn
Sep 2, 2017·Journal of Veterinary Internal Medicine·A GallerN Luckschander-Zeller
Oct 31, 2019·The Veterinary Record·Camilla Tørnqvist-JohnsenRichard J Mellanby
May 8, 2021·Journal of Veterinary Internal Medicine·Juan EstruchPhilip Bergman

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