Evaluation of gatifloxacin pluronic micelles and development of its formulation for ocular delivery

Drug Delivery and Translational Research
Jovita KanoujiaShubhini A Saraf

Abstract

The purpose of the present study was to enhance the solubility of gatifloxacin by developing self-assembling pluronic micelles of gatifloxacin for ocular delivery, to overcome the problem of poor bioavailability and therefore lesser therapeutic response exhibited by conventional ophthalmic solutions of the drug. Gatifloxacin was loaded in micelles by solid dispersion method using Pluronic F127 and evaluated for particle size, drug loading, loading efficiency, in vitro transcorneal permeation study, in vitro drug release, solubility studies, microbiological studies, ex vivo mucoadhesive strength, and ocular safety studies. The drug loading and drug loading efficiency studies revealed that gatifloxacin/Pluronic F127 ratio of 0.25/2.52 g offered good drug loading (9.96 %), high loading efficiency (90 %), and acceptable particle size of 176 nm (polydispersity index 0.345). Hen's egg test chorioallantoic membrane (HET-CAM) assay with 0 score in 8 h and ocular safety test with score of 2 indicate the nonirritant property of the developed pluronic micelles. In vitro transcorneal permeation studies through excised goat cornea indicated increase in ocular availability with no corneal damage. In vitro drug release data of optimized formu...Continue Reading

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Citations

May 23, 2015·Drug Development and Industrial Pharmacy·Avadhesh KushwahaHoward I Maibach
Apr 21, 2020·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Meltem Ezgi DurgunYıldız Özsoy
Oct 4, 2020·Pharmaceutics·Verônica da Silva OliveiraÁdley Antonini Neves de Lima
Dec 17, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Karolina MulasMarcin Sobczak
Dec 17, 2020·International Journal of Nanomedicine·Jiangxiu NiuYu Gan
Apr 9, 2021·Drug Delivery and Translational Research·Meltem Ezgi DurgunYıldız Özsoy

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