Evaluation of gene polymorphisms in exercise-induced oxidative stress and damage

Free Radical Research
Arthur K AkimotoMaria de Nazaré Klautau-Guimarães

Abstract

Many potentially significant genetic variants related to oxidative stress have been identified and performance in endurance sports is a multi-factorial phenotype. Thus, it was decided to investigate the influences of the haptoglobin (Hp), MnSOD (Val9Ala), CAT (21A/T), GPX1 (Pro198Leu), ACE, glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) genes' polymorphisms on the oxidative stress and damage suffered by human athletes (runners). Blood samples taken immediately after a race were submitted to genotyping, comet and TBARS assays, biochemical analyses of creatine kinase (CK), aspartate aminotransferase (AST) and alanine aminotransferase (ALT). MnSOD significantly influenced results of CK and a possible association between Hp1F-1S and Hp1S-2 genotypes with a superior TBARS values was found. Higher or lower TBARS and CK values or DNA damage also depended on the interaction between Hp and ACE or GST genotypes, indicating that MnSOD and Hp polymorphisms can be determining factors in performance, at least for runners.

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Citations

Jun 28, 2011·European Journal of Applied Physiology·Ana Luisa Miranda-VilelaMaria de Nazaré Klautau-Guimarães
Apr 26, 2011·European Journal of Applied Physiology·Ana Luisa Miranda-VilelaMaria de Nazaré Klautau-Guimarães
May 7, 2010·Environmental Health : a Global Access Science Source·Ana L Miranda-VilelaMaria N Klautau-Guimarães
Feb 26, 2014·Blood Cells, Molecules & Diseases·Lilian Carla BarbosaLeopoldo Luiz dos Santos-Neto
Sep 30, 2010·American Journal of Human Biology : the Official Journal of the Human Biology Council·Ana Luisa Miranda-VilelaCesar K Grisolia
May 29, 2014·Free Radical Research·I I AhmetovP Cieszczyk
Sep 3, 2013·Free Radical Research·S Ben-ZakenY Meckel
Aug 21, 2013·Free Radical Research·G BrescianiJ González-Gallego
Jun 14, 2016·European Journal of Applied Physiology·Philipp BaumertRobert M Erskine
Jan 14, 2011·Journal of Applied Physiology·Trent Stellingwerff, Asker E Jeukendrup
May 5, 2011·Journal of Applied Physiology·Jose L Chicharro

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