Evaluation of generations 2, 3 and 4 arginine modified PAMAM dendrimers for gene delivery

International Journal of Pharmaceutics
Hye Yeong NamJong-Sang Park

Abstract

It is a matter of concern to develop and design synthetic non-viral gene carriers with high transfection efficiency and low cytotoxicity in gene therapy. Recently, various arginine conjugated dendrimers showed better performance in transfection and greater viability than polyethyleneimine (PEI). In this study, we synthesized and investigated e-PAM-R G2, 3 and 4 which are biodegradable polyamidoamine (PAMAM) dendrimers modified with arginine and compared that with PAMAM-R series containing amide bonds for gene carriers. For plasmid DNA delivery, the transfection efficiency of e-PAM-R G4 was higher than G3 and G2 and similar to PAMAM-R G4 with favorable cell viability. Moreover, they indicated significantly higher suppression of TEL/AML1 protein, maybe due to rapid olidonucleotide (ODNs) release through biodegradability of e-PAM-R. These results suggest that biodegradable and non-toxic e-PAM-R may be useful carriers for the gene including plasmid DNA, antisense ODNs and si-RNA.

References

May 14, 1993·Science·R C Mulligan
Jul 30, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·W T GodbeyA G Mikos
Jul 8, 2000·Pharmaceutical Science & Technology Today·J D EichmanJ R Baker
Aug 23, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·J H JeongT G Park
Feb 5, 2003·Advanced Drug Delivery Reviews·Ching-Hsuan Tung, Ralph Weissleder
Sep 29, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Joon Sig ChoiJong-Sang Park
Jan 25, 2005·Bioorganic & Medicinal Chemistry Letters·Mitsuko MaedaKoichi Kawasaki
Feb 22, 2005·Advanced Drug Delivery Reviews·Hilary BrooksEric Vivès
Nov 29, 2005·Advanced Drug Delivery Reviews·Christine DufèsAndreas G Schätzlein
Jun 14, 2006·International Journal of Pharmaceutics·Joon Sig ChoiMinhyung Lee
Jul 18, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jung-Bin KimJa-Kyeong Lee
Jan 16, 2007·Biomaterials·Ji Hoon JeongSung Wan Kim
Aug 11, 2007·International Journal of Pharmaceutics·Benoît VromanVéronique Préat

❮ Previous
Next ❯

Citations

Jan 19, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Il-Doo KimJa-Kyeong Lee
Apr 25, 2009·BMC Biotechnology·Carolyn L WaiteCharles M Roth
Apr 17, 2013·International Journal of Nanomedicine·Songhie AnJong-Sang Park
Sep 26, 2013·Pharmaceutical Research·Ruijun XingXiaoyuan Chen
Jun 26, 2009·Expert Opinion on Drug Delivery·Xiubo ZhaoJian R Lu
Jul 30, 2009·Expert Opinion on Drug Delivery·Venkata K YellepeddiSrinath Palakurthi
Jul 30, 2009·Expert Opinion on Drug Delivery·Yoshie Maitani, Yoshiyuki Hattori
Apr 24, 2012·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Yuya HayashiHidetoshi Arima
Sep 8, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hidetoshi ArimaKaneto Uekama
Mar 15, 2011·International Journal of Pharmaceutics·Praneet OpanasopitTheerasak Rojanarata
Sep 22, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·In-Hyun LeeSangyong Jon
Dec 1, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Il-Doo KimJa-Kyeong Lee
Oct 10, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dzmitry ShcharbinMaria Bryszewska
Dec 21, 2010·Journal of Biomedical Materials Research. Part a·Jie LiuW Mark Saltzman
Mar 19, 2014·The Journal of Pharmacy and Pharmacology·Sahil P Chaplot, Ilva D Rupenthal
Jan 4, 2015·Drug Discovery Today·Prashant Kesharwani, Arun K Iyer
Sep 26, 2013·International Journal of Pharmaceutics·Hamideh ParhizMohammad Ramezani
Sep 19, 2015·PloS One·Valeria Márquez-MirandaFernando Danilo González-Nilo
Mar 12, 2010·Pharmaceuticals·Colin V Bonduelle, Elizabeth R Gillies
Jun 5, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yang ZhouJun Wu
Sep 15, 2012·Experimental and Therapeutic Medicine·Hui WangShan-Kai Yin
Nov 3, 2016·Chembiochem : a European Journal of Chemical Biology·Aurora SganappaAlessandro Volonterio
Jul 25, 2019·Current Pharmaceutical Design·Vijay MishraNamita Giri
Dec 2, 2020·Journal of Functional Biomaterials·Ekaterina O Mikhailova
Nov 6, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Youngki LeeMinhyung Lee
Jan 5, 2011·Bioconjugate Chemistry·Ullas Padinjaremattathil ThankappanNarayanaswamy Jayaraman
Jan 28, 2011·Biomacromolecules·Junjie DengLi-Ming Zhang
May 7, 2015·Chemical Reviews·Jiepin YangYiyun Cheng
Jul 14, 2011·Bioconjugate Chemistry·Christina Troiber, Ernst Wagner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

© 2022 Meta ULC. All rights reserved