Evaluation of genetic damage in human peripheral lymphocytes exposed to mineral trioxide aggregate and Portland cements

Journal of Oral Rehabilitation
M G BrazDaniel Araki Ribeiro

Abstract

summary Mineral trioxide aggregate (MTA) and Portland cement are being used in dentistry as root-end-filling material for periapical surgery and for the sealing of communications between the root canal system and the surrounding tissues. However, genotoxicity tests for complete risk assessment of these compounds have not been conducted up to now. In the present study, the genotoxic effects of MTA and Portland cements were evaluated in peripheral lymphocytes from 10 volunteers by the alkaline single cell gel (comet) assay. The results pointed out that the single cell gel (comet) assay failed to detect the presence of DNA damage after a treatment of peripheral lymphocytes by MTA and Portland cements for concentrations up to 1000 mug mL(-1). In summary, our results indicate that exposure to MTA or Portland cements may not be a factor that increases the level of DNA lesions in human peripheral lymphocytes as detected by single cell gel (comet) assay.

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Citations

Jul 25, 2009·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·R Steffen, H van Waes
Dec 29, 2010·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Talita Ribeiro Tenório de FrancaCarlos Menezes Aguiar
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Mar 12, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Amer Z AlaneziQiang Zhu
May 12, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Behnam JafarniaQiang Zhu
Jan 31, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Daniel Araki Ribeiro
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