Evaluation of glomerular lesion and abnormal urinary findings in OLETF rats resulting from a long-term diabetic state

The Journal of Laboratory and Clinical Medicine
Y FukuzawaN Hotta

Abstract

Otsuka Long-Evans Tokushima Fatty (OLETF) rats have been established as an animal model in which non-insulin-dependent diabetes mellitus develops spontaneously. We examined the renal histopathology and the urinary findings serially in OLETF rats and compared these findings with findings in age-matched Long-Evans Tokushima Otsuka (LETO) rats as a control strain. OLETF rats showed higher blood glucose levels than did LETO rats from 18 weeks of age, and hemoglobin A1c levels became higher in OLETF rats than in LETO rats from 22 weeks of age. Accompanying the development of hyperglycemia was an increase in the amount of albuminuria in OLETF rats from 18 weeks of age. The initial histopathologic change found in OLETF rats was an increase in glomerular area, and mesangial expansion started to develop from 22 weeks of age. Mesangial lesions progressed to mesangial sclerosis, and exudative lesions were found in OLETF rats from 36 weeks of age. The anionic charge of glomerular basement membrane (GBM), measured by polyethyleneimine grain density, demonstrated that the lower grain density in OLETF rats when compared with that in LETO rats became more evident with an increase in the amount of albuminuria. Therefore, the defect in the charg...Continue Reading

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