PMID: 9180231Jun 1, 1997Paper

Evaluation of glutathione S-transferase activity in human buccal epithelial dysplasias and squamous cell carcinomas

International Journal of Oral and Maxillofacial Surgery
Y K Chen, L M Lin

Abstract

Glutathione S-transferase (GST) activity and amount of GST alpha, mu and pi isoforms were measured in 40 patients with histopathologically confirmed oral epithelial dysplasia (OED) and squamous cell carcinoma of buccal mucosa. The results were compared with those of normal mucosa in an equal number of age- and sex-matched healthy controls. Mean total GST activities were significantly elevated from normal buccal mucosa for mild OED, moderate OED, severe OED and squamous cell carcinoma. GST activity of value approximating 100 nmol/min/mg distinguished between normal and dysplasia, and of value about 400 nmol/min/mg delineated between dysplasia and squamous cell carcinoma were observed. GST pi was the predominant class in both the diseased and normal buccal mucosa examined. This class pi GST was present at an intracellular concentration, which was significantly higher in diseased buccal mucosa than in normal buccal mucosa. These results indicated that pi class GST was the major form of this enzyme in the cytosolic fraction of oral mucosa. The severity of OED related to squamous cell carcinoma development seemed to increase concomitantly with an increase in the level of this enzyme. Further studies will validate the role of GST pi ...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Mar 1, 1991·The Biochemical Journal·D J MeyerB Ketterer
Aug 1, 1990·The Journal of Investigative Dermatology·A KonohanaM Duvic
Dec 1, 1986·International Journal of Oral and Maxillofacial Surgery
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B MannervikH Jörnvall
Aug 1, 1985·Journal of Oral Pathology·A Wright, M Shear
Aug 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Y K Chen, L M Lin
Mar 1, 1995·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·H LumermanS Kerpel
Jan 1, 1995·Virchows Archiv : an International Journal of Pathology·K ShimizuH Yoshida
Mar 1, 1995·Carcinogenesis·T P MulderA Wiersma
Feb 1, 1994·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·L ZhangR Priddy
Nov 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Y C KoC C Tsai

❮ Previous
Next ❯

Citations

Oct 9, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·R KumaraguruparanS Nagini
Oct 10, 2014·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·M Pérez-SayánsA García-García
Apr 27, 2010·Cancer Letters·Mario Pérez-SayánsAbel García-García
Jan 24, 2003·Expert Opinion on Therapeutic Targets·Laurent Gaté, Kenneth D Tew
May 25, 2006·Head & Neck·Gilka Jorge Figaro GattásVictor Wünsch-Filho

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

© 2021 Meta ULC. All rights reserved