Evaluation of glycofurol-based gel as a new vehicle for topical application of naproxen.

AAPS PharmSciTech
Nahla Salah Barakat

Abstract

In view of the good skin tolerability, glycofurol was used as a vehicle-based gel, and its effect in the topical penetration of Naproxen (NAP) was investigated. The aims of this study were to develop a suitable gel with bioadhesive property, spreadability, and viscosity for topical anti-inflammatory effect. Three gelling and adhesive agents were examined: Carbopol 974P, Gantrez AN 119, and polyvinylpyrollidone K30. Skin permeation rates and lag times of NAP were evaluated using the Franz-type diffusion cell in order to optimize the gel formulation. The permeation rate of NAP-based gel across the excised rat skin was investigated. A significant increase in permeability parameters such as steady-state flux (J(ss)), permeability coefficient (K(p)), and penetration index (PI) was observed in optimized formulation containing 2% Transcutol as an permeation enhancer. From skin irritation test, it was concluded that the optimized novel glycofurol-based gel formulation was safe to be used for topical drug delivery. The developed glycofurol-based gel appeared promising for dermal and transdermal delivery of naproxen and could be applicable with water-insoluble drugs, which would circumvent most of the problems associated with drug therapy.

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Citations

Jan 21, 2016·Pharmaceutical Development and Technology·Tomasz OsmałekMarcin Kapela
Jan 13, 2016·Drug Delivery and Translational Research·Rabinarayan ParhiSubasini Pattnaik
Jul 28, 2016·IET Nanobiotechnology·Norhayati Mohamed NoorAzila Abd Aziz
Dec 19, 2015·International Journal of Pharmaceutical Investigation·Kannissery PramodJaved Ali
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Aug 28, 2014·Pharmaceutical Development and Technology·Wiwat PichayakornGarnpimol C Ritthidej
Jul 30, 2014·Pharmaceutical Development and Technology·Junlin WangJianping Liu
May 15, 2015·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Chandra Kanti ChakrabortiPradipta Kumar Behera
Nov 14, 2018·AAPS PharmSciTech·David W Osborne, Jasmine Musakhanian
Jan 1, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Lorena Garcia-Del RioMariana Landin

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