Evaluation of hemocompatibility and in vitro immersion on microwave-assisted hydroxyapatite-alumina nanocomposites

Materials Science & Engineering. C, Materials for Biological Applications
G RadhaElangovan Vellaichamy

Abstract

This study reports the microwave-assisted synthesis and characterization of nHAp (nano-hydroxyapatite)-alumina composites. The crystalline phase and interaction of alumina with nHAp was analyzed using X-ray diffraction (XRD) and Raman microscopy analysis, respectively. High resolution transmission electron microscopy (HRTEM) micrographs exhibit morphological changes of nHAp composites with increasing alumina concentrations. Microhardness studies reveal the enhanced mechanical strength of nHAp10 and nHAp20 nanocomposites than pure nHAp. In vitro bioactivity of the nanocomposites was studied by immersing samples in simulated body fluid (Hank's solution) for 21 days. The surface of biomineralized samples were analyzed using field emission scanning electron microscopy (FESEM) and energy dispersive X-ray spectroscopy (EDX). Hemolytic assay revealed acceptable compatibility for varying concentrations of all the samples. Cell proliferation assay was systematically investigated for 1 day and 3 days on Saos-2 osteoblast-like cell lines and it was found that nHAp nanocomposites improved the proliferation.

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Citations

Jul 18, 2017·Journal of Tissue Engineering and Regenerative Medicine·Mostafa ShahrezaieJavad Parvizi
Feb 13, 2019·Journal of Materials Science. Materials in Medicine·S AarthyP Manohar
Apr 9, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·S ChitraS Balakumar
Feb 2, 2017·Beilstein Journal of Nanotechnology·Sylwia KuśnierukWitold Lojkowski
Apr 17, 2020·Journal of Biomedical Materials Research. Part a·Valarmathi NarayananArunai Nambi Raj Narayanasamy
Apr 1, 2019·Journal of Materials Science. Materials in Medicine·Chee-Heong OoiFei-Yee Yeoh
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Radha GS Balakumar

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