Evaluation of hepatic and kidney dysfunction among newly diagnosed HIV patients with viral hepatitis infection in Cape Coast, Ghana

BMC Research Notes
Nsoh Godwin AnabireSabastian Eliason

Abstract

HIV positive individuals infected with viral hepatitis B (HBV) or C (HCV) are at an increased risk of progression to kidney and liver failures. Therefore, prior to initiation of antiretroviral therapy, early diagnosis and initiation of appropriate treatment protocols are imperative for co-infected individuals. This study evaluated the prevalence of HBV and HCV, and extent of liver and renal dysfunction among 90 newly diagnosed HIV patients attending the Cape Coast Teaching Hospital HIV clinic. Levels of alanine aminotransferase, aspartate-platelet ratio index and estimated glomerular filtration rate were used respectively to diagnose hepatotoxicity, liver fibrosis and chronic kidney disease (CKD). Association analyses were evaluated by Pearson's Chi-square test or Fisher's exact test and considered significant at p < 0.05. Using rapid diagnostic tests, 75.6% (n = 68) had HIV1 mono-infection, 24.4% (n = 22) had HIV1/HBV co-infection while 0.0% (n = 0) had HIV1/HCV co-infection. The prevalence of hepatotoxicity, liver fibrosis, and CKD were 7.8% (n = 7), 2.2% (n = 2), and 15.5% (n = 14) respectively. Similar proportions of HIV1/HBV and HIV1 were diagnosed with liver fibrosis (p = 0.431). In relation to hepatotoxicity Grade, a hig...Continue Reading

References

Apr 3, 1998·American Journal of Epidemiology·F E MartinsonS M Lemon
Dec 15, 2005·Journal of Hepatology·Miriam J Alter
May 25, 2007·The Lancet Infectious Diseases·Christopher J Hoffmann, Chloe L Thio
Apr 29, 2009·Journal of Hepatology·Julie BotteroPierre-Marie Girard
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
May 7, 2010·European Journal of Health Law·André Pereira
May 15, 2010·BMC Infectious Diseases·Michelle DallaPiazzaVincent Lo Re
Jun 12, 2010·Bulletin of the World Health Organization·Rashida FerrandElizabeth L Corbett
Aug 17, 2010·Postgraduate Medical Journal·Elias C ChackoJoseph M Pappachan
May 11, 2011·Antiviral Therapy·Lara StabinskiUNKNOWN Rakai Health Sciences Program
Nov 16, 2011·Nigerian Medical Journal : Journal of the Nigeria Medical Association·Rose A Ugiagbe, Emeka U Eze
Apr 26, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·George N IoannouEdward J Boyko
Jun 30, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Philippa C MatthewsPaul Klenerman
Mar 1, 2015·Clinical Nephrology·Saraladevi NaickerJeffrey B Kopp
Nov 3, 2016·Tropical Medicine & International Health : TM & IH·Michael J VinikoorUNKNOWN International Epidemiologic Databases to Evaluate AIDS in Southern Africa (IeDEA-SA)
Sep 20, 2016·Journal of Hepatology·Patrice CacoubClodoveo Ferri
Dec 17, 2016·AIDS Research and Human Retroviruses·François GoehringerThierry May
Aug 9, 2017·Journal of the American Society of Nephrology : JASN·Vasantha JotwaniMichelle M Estrella
Nov 17, 2017·BMC Infectious Diseases·Patrick A CoffieUNKNOWN IeDEA collaboration
Feb 7, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Norah A TerraultJohn B Wong
Oct 23, 2018·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Gideon Kofi HelegbeErnest Ofosu

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Citations

Nov 22, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Bernard SurialGilles Wandeler

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