Evaluation of hepatic fibrosis by ultrasonic acoustic structure quantification

Medicine
Lei ChengJia Guo

Abstract

To evaluate the diagnostic accuracy of ultrasonic acoustic structure quantification (ASQ) for grading hepatic fibrosis/cirrhosis by comparing ultrasonographic features of regions of interest on ASQ images with the pathological characteristics of stage F0-F4 hepatic fibrosis cases.We retrospectively analyzed the medical records of 97 patients with chronic hepatitis who underwent ASQ evaluation at the Ultrasound Room of Dongfang Hepatobiliary Surgery Hospital (Shanghai, China) between July 2012 and October 2013. Regions of interest on stored ASQ images were analyzed to obtain cm values on modes, averages, and standard deviations. Correlation analysis, principal component analysis (PCA), and multivariate analysis of variance (MANOVA) of the mean cm values with hepatic fibrosis staging were performed. A receiver operating characteristic (ROC) curve was used to assess the diagnostic accuracy of ASQ.The mean cm of ASQ correlated with the pathological stage of hepatic fibrosis, with the best correlation coefficient (r = 0.81) in the right lobe below rib 2. The best cm average 1 and 2 values, which differed significantly among different hepatic fibrosis/cirrhosis stages, were also found in this area. The maximal area under the ROC curv...Continue Reading

References

Dec 1, 1995·The American Journal of Surgical Pathology·K P Batts, J Ludwig
Aug 1, 1993·Radiology·K A MilesA K Dixon
Mar 23, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Tetsuya KanekoAkimasa Nakao
Mar 16, 2006·European Journal of Gastroenterology & Hepatology·Juliette FoucherVictor de Lédinghen
May 7, 2015·World Journal of Gastroenterology : WJG·Thomas KarlasVolker Keim
Jun 19, 2017·Best Practice & Research. Clinical Gastroenterology·Miguel Eugenio ZoubekPavel Strnad

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Methods Mentioned

BETA
biopsy
PCA

Software Mentioned

FibroScan
SAS9
SPSF13
ASQ
R2

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