Evaluation of hepatic injury in acute carbon monoxide-poisoned patients in emergency department.

Human & Experimental Toxicology
S J KimH Kim

Abstract

The affinity of hemoglobin for carbon monoxide (CO) is 250 times higher than that for oxygen. Therefore, exposure to CO leads to a reduction in oxygen delivery to tissues, resulting in cellular hypoxia and affects whole body. Hepatic dysfunction in critically ill patients is related to poor outcome, but few studies have been conducted on this subject that occurs after CO poisoning. This study aims to conduct a study of hepatic injury in CO-poisoned patients in emergency department (ED). This retrospective observational study collected data from patients who were diagnosed with acute CO poisoning at the ED between June 2011 and May 2018 in local tertiary-care hospital (Wonju, Republic of Korea). The primary end point of this study was to describe the prevalence of hepatic injury in acute CO-poisoned patients. The secondary goals were to investigate the recovery trends of hepatic injury caused by acute CO poisoning and the relation to neurologic outcome and mortality. Eight hundred ninety-four patients were enrolled in the final analysis, 128 cases (14.3%) had subclinical hepatic injury and 15 (1.6%) cases had hepatic injury. The relationship with mortality was not statistically significant. However, the hepatic injury group was ...Continue Reading

References

Nov 1, 1979·Digestive Diseases and Sciences·J A Cohen, M M Kaplan
Jul 1, 1983·Archives of Neurology·I S Choi
Jan 1, 1982·Annual Review of Physiology·P D Richardson, P G Withrington
Jun 20, 1996·The New England Journal of Medicine·P M Tibbles, J S Edelsberg
Nov 26, 1998·The New England Journal of Medicine·A Ernst, J D Zibrak
Jan 30, 1999·Postgraduate Medicine·C Tomaszewski
Apr 18, 2000·Critical Care Clinics·J L VincentR Moreno
Jul 4, 2003·Postgraduate Medical Journal·J K Limdi, G M Hyde
Feb 24, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul B Watkins, Leonard B Seeff
Mar 6, 2007·Critical Care Medicine·Ludwig KramerUNKNOWN Austrian Epidemiologic Study on Intensive Care, ASDI Study Group
Jul 20, 2007·Internal Medicine·Richard BirrerTsuyoshi Takara
Jun 26, 2009·The New England Journal of Medicine·Michael R LuceyTimothy R Morgan
Apr 22, 2010·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Kathryn WeibrechtSteven B Bird
Dec 15, 2010·Journal of Anesthesia·Joan M RaurichJordi Ibáñez
Oct 1, 2012·Hepatology International·Goolab TrilokXu Li-Jun
Sep 4, 2015·The New England Journal of Medicine·Christian TemplinThomas F Lüscher
Feb 25, 2019·The American Journal of Emergency Medicine·Mikio NakajimaHideo Yasunaga

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