Evaluation of hepatitis B surface antibody and specific gamma interferon response in health care workers after vaccination

Jundishapur Journal of Microbiology
Mohammad Hosein Sarmast ShooshtariFardin Ghaedi

Abstract

Health care workers are at high risk of acquiring hepatitis B virus (HBV) infection through occupational exposure to blood or body fluids. Thus, the assessment of anti-HBs status after immunization is very important. This study aimed to evaluate the measurement of HBsAb titer and specific gamma interferon response among the vaccinated health care workers in Golestan Hospital, Ahvaz, Iran. The blood samples of 39 health care workers, including 13 general surgeons, 10 anesthesiologists, 5 neurosurgeons, 3 general physicians, 1 orthopedist, 2 urologist and 5 nurses were collected during June 2013. All the participants had received HBV vaccine. They had received last vaccine dose from 2 months to 14 years ago. Their sera were tested for anti-hepatitis B antibody and HBc-IgG by the ELISA. Also, the evaluation of specific interferon γ response against HBsAg was carried out using ELISA test. The age of health care workers were between 24 and 58 years with the mean age of 34.3 ± 7.4 y. Out of 39 sera, 22 (56.41%) had HBsAb titer above 100 IU/mL, 17 (43.6%) had titer below 100 IU/mL, 27 (69.2%) had positive specific HBsAg interferon γ, 8 (20.5%) cases had positive antibody response above 100IU, but negative for specific interferon γ and...Continue Reading

References

Jul 4, 1998·American Journal of Preventive Medicine·G A Poland
Oct 21, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eishiro MizukoshiBarbara Rehermann
Dec 31, 2004·The New England Journal of Medicine·Gregory A Poland, Robert M Jacobson
Nov 8, 2005·The American Journal of Medicine·Maria H Sjogren
Nov 29, 2005·Vaccine·Maryline Mancini-BourgineMarie-Louise Michel
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Jan 12, 2008·European Journal of Gastroenterology & Hepatology·Seyed-Moayed AlavianSeyed-Mohammad Miri
Sep 1, 2009·Viruses·Antonio BertolettiAdam J Gehring
Apr 19, 2013·World Journal of Gastrointestinal Pathophysiology·Dimitra DimitropoulouCharalambos A Gogos

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Citations

Sep 4, 2015·World Journal of Hepatology·Liliane C MeirelesPierre Van Damme

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Methods Mentioned

BETA
Assay
ELISA
density gradient centrifugation

Software Mentioned

SPSS

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