Evaluation of hepatitis B vaccine efficacy and factors affecting vaccine nonresponse in patients receiving anti-tumor necrosis factor agents.

European Journal of Gastroenterology & Hepatology
Gülay OkayMeliha Meric Koc

Abstract

The response rate of patients to hepatitis B virus (HBV) vaccination receiving anti-tumor necrosis factor (TNF) agents is quite low. We aimed to assess the efficiency of HBV vaccination in patients with chronic inflammatory diseases (CIDs) receiving anti-TNF agents as well as in healthy controls. We also evaluated the impact of different factors on the efficacy of HBV vaccination. Patients with CIDs receiving anti-TNF agents and healthy controls vaccinated for HBV were included in the study during 2018-2019. An adequate immune response and an effective immune response to HBV were defined as >10 IU/L and > 100 IU/L, respectively. Among 274 participants, 187 were patients with CID and 87 were healthy controls. The mean age of the patients with CID (43.9 ± 11.7 years) was significantly higher than that of the healthy controls (31.4 ± 7 years) (P = 0.000). Adequate immune response was 60.8 and 94.3% in patients with CID and healthy controls (P = 0.000), respectively, whereas effective immune response was 37.9 and 75.9% (P = 0.000), respectively. In logistic regression analysis, male sex [odds ratio (OR), 0.408; 95% confidence interval (CI), 0.201-0.830; P = 0.013), use of infliximab (OR, 2.694; 95% CI, 1.203-6.035; P = 0.016) and s...Continue Reading

References

Jan 16, 1997·The New England Journal of Medicine·S M Lemon, D L Thomas
Mar 8, 2006·World Journal of Gastroenterology : WJG·Gunda MillonigWolfgang Vogel
Jul 5, 2006·The American Journal of Gastroenterology·Gil Y MelmedEric A Vasiliauskas
Jan 9, 2007·Inflammatory Bowel Diseases·Salvatore MadoniaMario Cottone
Nov 10, 2009·Vaccine·UNKNOWN WHO Publication
Jun 26, 2010·Gut·C LorasUNKNOWN GETECCU (Grupo Español de Enfermedades de Crohn y Colitis Ulcerosa) Group
Jul 2, 2010·Rheumatology·Jean-François RahierFilip De Keyser
Mar 26, 2011·Inflammatory Bowel Diseases·Iris DotanLloyd Mayer
Dec 8, 2011·Digestive Diseases and Sciences·Mustafa Erhan AltunözAyşe Oya Kurdaş Ovünç
May 15, 2015·Journal of Gastroenterology and Hepatology·Patrícia AndradeGuilherme Macedo
Jun 30, 2015·European Journal of Gastroenterology & Hepatology·Arthur BelleLaurent Peyrin-Biroulet
Jan 11, 2017·The American Journal of Gastroenterology·Francis A FarrayeSunanda V Kane
Jul 27, 2017·Vaccine· World Health Organization
Jan 25, 2019·Human Vaccines & Immunotherapeutics·Asli Haykir Solay, Fatma Eser

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Citations

Mar 20, 2021·Rheumatology International·Figen ÇakmakBetül Sözeri

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