PMID: 8604888Apr 1, 1996Paper

Evaluation of HER-2/neu (c-erbB-2) oncogene expression in whole organ sections of supraglottic squamous cell carcinoma

The Annals of Otology, Rhinology, and Laryngology
G S WeinsteinK Montone

Abstract

Adequate pathologic material and careful clinical follow-up are prerequisites for the analysis of the expression of particular oncogenic proteins that are prognostically important in squamous cell carcinoma of the larynx. The Gabriel Tucker, Jr, Collection of 150 whole organ specimens allows for the potential immunohistochemical study of the entire tumor. Sections from 32 supraglottic carcinomas were studied immunohistochemically for the presence of HER-2/neu (c-erbB-2) oncogene expression. Long-term follow-up data were available in all cases to assist in determining the prognostic significance of the specified oncogene in supraglottic squamous cell carcinoma. Our study revealed that joint presentation of immune staining for c-erbB-2 and positive lymph node status was significantly associated with distant metastasis (p=.00760).

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Citations

Mar 10, 2004·Oral Oncology·David UlanovskiRaphael Feinmesser
Mar 4, 2000·Cancer Investigation·H YaziciN Dalay
Feb 13, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Giovanni AlmadoriFranco O Ranelletti
Dec 24, 2015·Journal of Dental Research, Dental Clinics, Dental Prospects·Naga Jyothi MekaStuti Goyal
Feb 7, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Francesca AngieroAngelo Sidoni
Sep 4, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Yasaman SardariMarzieh Hamzavi
Jun 25, 1999·Acta Oto-laryngologica·T KrecickiM Zalesska-Krecicka
Feb 19, 2002·Cancer Genetics and Cytogenetics·Jian YanYi Xin Zeng

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