Evaluation of histocompatibility as a factor in the repair of nerve with a frozen nerve allograft

Journal of Neurosurgery
A A Zalewski, A K Gulati

Abstract

Host axons in dogs can regenerate through a long nerve allograft provided that the allograft bears only minor transplantation antigens, and is frozen and thawed before transplantation. The authors have tried to confirm this important observation in rats. Host rats received a 4-cm fresh or frozen nerve isograft (that is, a non-antigenic nerve), or a fresh or frozen nerve allograft with cells containing only minor transplantation antigens. The results showed that after 2 and 9 months only a fresh isograft permitted many host axons to traverse its entire length. Only a few host axons grew into the proximal 1 to 2 cm of a frozen isograft or into an allograft (fresh or frozen). Because frozen grafts failed, the authors examined some specimens after 2 weeks and found that freezing killed most of the Schwann cells. on the other hand, many proliferating Schwann cells were found in 2-week fresh isografts. In addition, hosts that received a frozen nerve allograft underwent regrafting after 9 months with an isograft and allograft (of the same genotype as th original nerve allograft) of nodose ganglion. These rats accepted the isograft but rejected the allograft of ganglion. It is concluded that axonal regeneration through a long frozen ne...Continue Reading

References

Nov 1, 1977·Journal of Neurosurgery·R SinghS Stefanko
Jan 30, 1973·Acta Neuropathologica·J D Pollard, L Fitzpatrick
Mar 1, 1974·Plastic and Reconstructive Surgery·C D Bucko, D Steinmuller
Jun 1, 1967·Brain : a Journal of Neurology·R A Lehman, G J Hayes
Jan 1, 1971·Annales de génétique et de sélection animale·J J ColleauP Derveaux

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Citations

Oct 1, 1995·Muscle & Nerve·P J EvansR Midha
Feb 1, 1997·Molecular Neurobiology·S Y Fu, T Gordon
Mar 1, 1984·Experimental Neurology·A A Zalewski, A K Gulati
Jun 1, 1994·Progress in Neurobiology·P J EvansS E Mackinnon
Dec 14, 2004·Tissue Engineering·Terry W HudsonChristine E Schmidt
Feb 3, 2005·Tissue Engineering·Terry W HudsonChristine E Schmidt
Aug 29, 2012·Tissue Engineering. Part B, Reviews·Mark SzynkarukGregory H Borschel
Sep 1, 1986·Journal of Neurosurgery·J W Fawcett, R J Keynes
Dec 10, 2008·Neurosurgery Clinics of North America·Jae W SongStephen M Russell
Apr 30, 2013·Muscle & Nerve·Nithya J JesurajShelly E Sakiyama-Elbert
Jan 1, 1986·Annals of the New York Academy of Sciences·P M Richardson, R J Riopelle
Nov 1, 1983·Neuropathology and Applied Neurobiology·P N AndersonV V Stauber
Jan 1, 1989·Annales De Chirurgie De La Main : Organe Officiel Des Sociétés De Chirurgie De La Main·D KatzD Henin
Mar 2, 2016·Biotechnology and Bioengineering·Leyla ZilicJohn W Haycock
Oct 5, 2016·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Jae Kwang KimDong Hyuk Seo
May 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·T Trumble, J Stanislaw
Oct 1, 1989·Journal of Neuroscience Research·J SketeljM Popović
Jan 5, 2014·European Surgery : ACA : Acta Chirurgica Austriaca·P J JohnsonS E Mackinnon
Dec 4, 2020·Neural Regeneration Research·Arash ZaminyAdib Zendedel
Apr 4, 2021·International Journal of Molecular Sciences·Tim KornfeldChristine Radtke
Aug 20, 1982·The Journal of Comparative Neurology·A A ZalewskiA K Gulati

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