Evaluation of histological structure and its effect on the distribution of alpha1-adrenoceptors in human benign prostatic hyperplasia

British Journal of Urology
S KurimotoK Kawabe

Abstract

To evaluate the histological structure of benign prostatic hyperplasia (BPH) and its relationship with the density of alpha1-adrenoceptors in smooth muscle. Specimens from hyperplastic tissues obtained from 14 patients with BPH were evaluated for the density of alpha1-adrenoceptors in smooth muscle using autoradiography, Mallory-Azan staining and computer-assisted image analyses. The binding of [3H] tamsulosin (a selective alpha1-blocker) and the ratio of smooth muscle area was calculated, and the density of alpha1-adrenoceptors per area of smooth muscle determined by dividing the degree of binding by the ratio of smooth muscle to total area. There was a significant difference between the ratio of smooth muscle area in the hyperplastic acinar nodule and the surrounding stroma (P < 0.01). The density of alpha1-adrenoceptor per smooth muscle area was significantly higher in the hyperplastic acinar nodule than in the surrounding stroma (P < 0.05). There was no correlation between prostatic weight and the ratio of smooth muscle area or the density of alpha1-adrenoceptors in each region. The distribution of alpha1-adrenoceptors on smooth muscle differed with histological structure; both the histological conformation and the differen...Continue Reading

References

Mar 1, 1990·The Journal of Urology·K KawabeT Ishima
Jan 1, 1990·European Urology·Y I SiegelA Lindner
Dec 1, 1973·British Journal of Urology·S RazM Caine
Nov 1, 1994·General Pharmacology·N MoriyamaK Kawabe
Sep 1, 1994·International Journal of Urology : Official Journal of the Japanese Urological Association·K KawabeN Taniguchi
Jun 30, 1994·Biochemical and Biophysical Research Communications·D H WeinbergM Bayne

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