Evaluation of hot-melt extrusion and injection molding for continuous manufacturing of immediate-release tablets

Journal of Pharmaceutical Sciences
Alice MelocchiLucia Zema

Abstract

The exploitation of hot-melt extrusion and injection molding for the manufacturing of immediate-release (IR) tablets was preliminarily investigated in view of their special suitability for continuous manufacturing, which represents a current goal of pharmaceutical production because of its possible advantages in terms of improved sustainability. Tablet-forming agents were initially screened based on processability by single-screw extruder and micromolding machine as well as disintegration/dissolution behavior of extruded/molded prototypes. Various polymers, such as low-viscosity hydroxypropylcellulose, polyvinyl alcohol, polyvinyl alcohol-polyethylene glycol graft copolymer, various sodium starch glycolate grades (e.g., Explotab(®) CLV) that could be processed with no need for technological aids, except for a plasticizer, were identified. Furthermore, the feasibility of both extruded and molded IR tablets from low-viscosity hydroxypropylcellulose or Explotab(®) CLV was assessed. Explotab(®) CLV, in particular, showed thermoplastic properties and a very good aptitude as a tablet-forming agent, starting from which disintegrating tablets were successfully obtained by either techniques. Prototypes containing a poorly soluble model ...Continue Reading

References

Sep 2, 1999·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A Rothen-WeinholdR Gurny
Sep 9, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mamoru FukudaJames W McGinity
Jan 6, 2007·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sandrien JanssensGuy Van den Mooter
Jun 6, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Thomas QuintenChris Vervaet
Dec 5, 2009·Journal of Pharmaceutical Sciences·G E GraneroD M Barends
Nov 16, 2010·The Journal of Pharmacy and Pharmacology·Gavin P AndrewsDavid S Jones
Dec 8, 2011·Expert Opinion on Drug Delivery·Michael A RepkaNoorullah Naqvi Mohammed
Jan 17, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lucia ZemaAndrea Gazzaniga
Jun 12, 2012·International Journal of Pharmaceutics·Lucia ZemaAndrea Gazzaniga
Nov 20, 2012·Journal of Pharmaceutical Sciences·Lucia ZemaAndrea Gazzaniga
Nov 28, 2012·International Journal of Pharmaceutics·Sejal ShahMichael A Repka
Jan 11, 2013·Drug Development and Industrial Pharmacy·Prateek DaniA K Bansal
Jan 22, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jelena DjurisKyriakos Kachrimanis
Jan 26, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Justin R HugheyJames W McGinity
Mar 15, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Bart ClaeysChris Vervaet
May 25, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·J VercruysseC Vervaet
Jul 31, 2013·Drug Discovery Today·Alexander SchuhmacherOliver Gassmann
Nov 12, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Giulia LoretiLucia Zema
Jul 11, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·L DierickxC Vervaet

❮ Previous
Next ❯

Citations

Jan 13, 2016·Drug Development and Industrial Pharmacy·Marcos LlusaJohannes Khinast
May 25, 2016·International Journal of Pharmaceutics·Alice MelocchiLucia Zema
Jan 4, 2017·Journal of Pharmaceutical Sciences·Ajinkya M BhagurkarS Narasimha Murthy
Apr 23, 2019·Expert Opinion on Drug Delivery·Venkata Raman KallakuntaMichael A Repka
Sep 14, 2018·The AAPS Journal·Ziyaur RahmanMansoor A Khan
Jan 27, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Rydvikha GovenderStaffan Folestad
Mar 29, 2021·Advanced Drug Delivery Reviews·Alice MelocchiAndrea Gazzaniga
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Stéphane RoulonJean Alié
Jun 21, 2021·Journal of Pharmaceutical Sciences·Ryoma TanakaMakoto Otsuka
Jun 21, 2021·Advanced Drug Delivery Reviews·Muhammad Sohail ArshadKendal Pitt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.