Evaluation of hot-pressed hydroxyapatite/poly-L-lactide composite biomaterial characteristics

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Nenad IgnjatovicDragan Uskokovic

Abstract

Hydroxyapatite/poly-L-lactide (HAp/PLLA) is a ceramic/polymer composite, whose application as a resorbable biomaterial for the substitution and repair of hard bone tissue is widely promising in orthopedic, oral, maxillofacial, and reconstructive surgery. Hot processing is a necessary step for obtaining HAp/PLLA composite blocks with mechanical properties similar to those of bones. In this article, the changes in structure and physicochemical properties of HAp/PLLA composite, hot pressed for different pressing times (5, 15, 30, 45, and 60 min), were studied. Because the morphology of HAp/PLLA composite biomaterial is very sensitive to this procedure, its surface microstructure was analyzed by scanning electron microscopy (SEM) coupled with an energy-dispersive X-ray (EDX) detector system. Structural changes occurring in the material, mostly changes in crystallinity of PLLA, were studied by wide-angle X-ray structural analyses (WAXS) and infrared (FTIR) spectroscopy. Using differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and gel permeation chromatography (GPC), the influence of hot pressing on the properties, crystallization kinetics, and decomposition of HAp/PLLA composite biomaterial was analyzed.

References

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Citations

Mar 11, 2010·Journal of Materials Science. Materials in Medicine·C MakarovE Y Gutmanas
Sep 16, 2011·Journal of Materials Science. Materials in Medicine·Erkin AydinVasif Hasirci
Aug 12, 2015·Journal of Functional Biomaterials·Sergey V Dorozhkin
Dec 15, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Artoum RakovskyElazar Y Gutmanas
Nov 10, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Vuk Uskoković, Dragan P Uskoković
Apr 18, 2016·Advanced Drug Delivery Reviews·Marius Murariu, Philippe Dubois
Oct 20, 2005·Journal of Bioscience and Bioengineering·Yoshihiro ItoOh Hyeong Kwon
Aug 19, 2007·Journal of Biomedical Materials Research. Part a·Yasuhiro Tanimoto, Norihiro Nishiyama
Apr 8, 2020·Journal of Materials Science. Materials in Medicine·Muna M Kareem, K Elizabeth Tanner
Jun 4, 2019·Journal of Biomaterials Science. Polymer Edition·Cijun ShuaiYouwen Deng
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Filipe V FerreiraLuiz H C Mattoso
Apr 3, 2012·Journal of Applied Biomaterials & Functional Materials·Marija Ð VukelićStevo J Najman
Oct 28, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Jordi SansCarlos Alemán
Dec 5, 2017··Mohd Reusmaazran YusofA. A. Kamarolzaman

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