Evaluation of hydrate formation of a pharmaceutical solid by using diffuse reflectance infrared Fourier-transform spectroscopy

Journal of Pharmaceutical and Biomedical Analysis
Takashi KojimaYoshiko Tsuda

Abstract

Ampicilline and nitrofurantoin, in both anhydrous and hydrate forms, were characterized by powder X-ray diffractometry (PXRD), thermogravimetric and differential thermal analyses (TG/DTA) and diffuse reflectance FT-IR spectroscopy (DRIFTS). Of all the analytical tools applied, only DRIFTS was able to indicate the formation of hydrogen bonds between the molecules of the anhydrous drug substance and crystalline water uptaken from atmospheric moisture as evidenced by the significant absorption at 3500-3700cm(-1) corresponding to crystal water. These results suggested that DRIFTS could provide information on hydration without a standard sample and accurately evaluate the physical stability focusing on the qualification of slight hydration in the early stages of pharmaceutical development. In addition, DRIFTS was applied to the besylate salt of pharmaceutical compound A to identify any possible hydration. This salt had the stable form BSA-I, metastable form BSA-II and hydrate form BSA-III. DRIFTS was able to show the hydration of BSA-II even when stored in a capped bottle, eventually leading to the transformation into BSA-III, which was not detected by PXRD. These findings verify the usefulness of DRIFTS for the solid-state characte...Continue Reading

References

Apr 28, 2001·Advanced Drug Delivery Reviews·D E Bugay
Apr 28, 2001·Advanced Drug Delivery Reviews·S R ByrnA W Newman
May 30, 2001·Journal of Pharmaceutical and Biomedical Analysis·S Agatonovic-KustrinI G Tucker

❮ Previous
Next ❯

Citations

Jul 2, 2009·Journal of Pharmaceutical Sciences·F TianJ Rantanen
Nov 7, 2009·Journal of Pharmaceutical Sciences·Harry G Brittain
Jan 18, 2011·Journal of Pharmaceutical and Biomedical Analysis·Norman ChiengJaakko Aaltonen
Jul 27, 2010·Journal of Pharmaceutical and Biomedical Analysis·Marta ŁaszczMagdalena Glice
Sep 10, 2014·Journal of Pharmaceutical and Biomedical Analysis·C BaraldiM C Gamberini
May 8, 2009·Analytical Chemistry·R K Gilpin, C S Gilpin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.