Evaluation of hypochromic erythrocytes in combination with sTfR-F index for predicting response to r-HuEPO in anemic patients with multiple myeloma

Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology
Eirini KatodritouJohn Christakis

Abstract

The purpose of this study was to evaluate the sTfR-F index and hypochromic erythrocytes (HYPO%) as potential predictors of response to recombinant human erythropoietin (r-HuEPO) of anemic patients with multiple myeloma (MM) before treatment, as well as early in the course of treatment. Twenty-six newly diagnosed anemic MM patients received r-HuEPO 30,000 IU/wk sc, for six weeks. The sTfR-F index and HYPO% were determined at baseline and at weeks 2 and 6. Patients were classified in 1 of 4 categories of a diagnostic plot, according to erythropoietic state (ES I-IV), defined by the combination of sTfR-F index and HYPO%. Sixteen of 20 patients in ES I and II before treatment responded to r-HuEPO, whereas none of the 6 patients in ES III and IV responded (P < .001). At week 2, 44% of patients who responded and 60% of the nonresponders were in functional iron deficiency (FID) and the proportion increased to 69% and 80%, respectively, by week 6. Seven of the patients who did not respond received in addition 200 mg iron sucrose IV weekly, for the next 4 weeks, and 6 of them responded. These results suggest that combination of sTfR-F index and HYPO% in a diagnostic plot can be used as a predictive model to recognize patients who will b...Continue Reading

References

Jan 1, 1977·Transactions - American Society for Artificial Internal Organs·J W Eschbach, J D Cook
Dec 1, 1977·Annals of Internal Medicine·J W EschbachC A Finch
Jan 25, 1992·BMJ : British Medical Journal·I C MacdougallJ D Williams
May 1, 1994·The American Journal of the Medical Sciences·S B Krantz
Aug 1, 1995·Leukemia & Lymphoma·Y Beguin
Mar 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J GlaspyS Vadhan-Raj
Jun 1, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J BraunW H Hörl
Mar 3, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M P KooistraJ J Marx
May 6, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·I C Macdougall
Mar 20, 1999·Kidney International. Supplement·D S SilverbergA Iaina
Mar 20, 1999·Kidney International. Supplement·E D Weinberg
Dec 13, 2000·The Journal of Biological Chemistry·C H ParkT Ganz
Jun 28, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·N TessitoreG Maschio
Jul 12, 2002·The Hematology Journal : the Official Journal of the European Haematology Association·Heinz LudwigDimitrios Voliotis
Oct 29, 2002·Best Practice & Research. Clinical Haematology·I Cavill
Mar 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael AuerbachJeevindra Rana
Mar 26, 2005·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Christian Thomas, Lothar Thomas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.