Evaluation of hypoglycemic and anti-hyperglycemic potential of Tridax procumbens (Linn.).

BMC Complementary and Alternative Medicine
Hemant PareekG C Jain

Abstract

Diabetes is a metabolic disorder affecting carbohydrate, fat and protein metabolism. Tridax procumbens Linn. (Family-Asteraceae; common name-Dhaman grass) is common herb found in India. Traditionally, the tribal inhabitants of Udaipur district in Rajasthan (India) uses the leaf powder (along with other herb) orally to treat diabetes. There is a need to evaluate extracts of this plant in order to provide scientific proof for it's application in traditional medicine system. Extraction of whole plant of T. procumbens using 50%methanol. The extract was tested for acute and sub-chronic anti-hyperglycemic activity in alloxan induced diabetic rats and for acute toxicity test among normal rats. Observations on body weight as well as on the oral glucose tolerance levels were also recorded. Oral administration of acute and sub chronic doses (250 and 500 mg/kg b.wt.) of T. procumbens extract showed a significant (p < 0.05) reduction in fasting blood glucose levels in diabetic rats, however the decline in blood sugar levels in normal rats was not observed. In acute study the maximum percent blood glucose reduction (68.26% at 250 mg/kg and 71.03% at 500 mg/kg body weight) in diabetic rats was observed at 6 h. The anti-hyperglycemic effects ...Continue Reading

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Citations

Apr 10, 2013·Asian Pacific Journal of Tropical Biomedicine·G Rajiv Gandhi, P Sasikumar
Apr 10, 2013·Asian Pacific Journal of Tropical Biomedicine·D K PatelS Hemalatha
May 7, 2013·Asian Pacific Journal of Tropical Biomedicine·Khalid AlgaririNorhyati Ismail
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