PMID: 16628284Apr 22, 2006Paper

Evaluation of hypothalamic-pituitary-adrenal axis recovery after corticotherapy by using basal cortisol secretion

Arquivos brasileiros de endocrinologia e metabologia
Ivani Novato SilvaEnrico A Colosimo

Abstract

The glucocorticoid-induced inhibition that occurs after discontinuation of treatment is the most frequent cause of adrenal insufficiency. There are yet some doubts about the best way of evaluating the hypothalamic-pituitary-adrenal (HPA) axis in those patients. The main objective of this study was to evaluate the utility of basal cortisol in diagnosing adrenal insufficiency. Thirty-five children with acute lymphoid leukemia (ALL) receiving glucocorticoid therapy (median age of 6.9 years) were evaluated. A stimulus test with corticotropin releasing hormone (CRH-1 mcg/kg) was performed before the introduction of dexamethasone (6 mg/m2/day, for 28 days), in the 8th and the 28th days of glucocorticoid therapy, and 48 hours and one month after discontinuation of therapy. Suppression of the basal secretion as well as the maximum concentration of cortisol (post-CRH) occurred during glucocorticoid therapy, which persisted for 48 hours after the steroid was removed from treatment (p< 0.01 and p< 0.0001, respectively, for the three tests). One month after ceasing the administration of the glucocorticoid, the basal secretion, as well as the maximum concentration of cortisol, were similar to that before glucocorticoid therapy. There was a ...Continue Reading

References

Sep 15, 1992·Hospital Practice·J D Baxter
Feb 1, 1970·Archives of Disease in Childhood·W A Marshall, J M Tanner
Sep 1, 1971·The Journal of Pediatrics·H G Morris, J R Jorgensen
Jun 1, 1969·Archives of Disease in Childhood·W A Marshall, J M Tanner
Aug 1, 1994·Respiratory Medicine·J W Honour
Nov 5, 1997·The New England Journal of Medicine·S W LambertsF H de Jong
Mar 23, 1999·Archives of Disease in Childhood·J C AgwuC G Brook
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Cristiane de Freitas CunhaFrancisca Lee Finch

❮ Previous
Next ❯

Citations

Oct 31, 2009·European Journal of Clinical Investigation·L JollinK Collomp
Aug 19, 2015·The Cochrane Database of Systematic Reviews·Maartje S GordijnGertjan J L Kaspers
Apr 12, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kanakadurga SingerThomas P Shanley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.