Evaluation of IL-29 in Euthyroid Patients with Graves' Orbitopathy: A Preliminary Study.

Mediators of Inflammation
Bogusz FalkowskiMarek Ruchala

Abstract

The most frequent cause of hyperthyroidism is Graves' disease (GD). Orbitopathy is the most prevalent and recognizable extrathyroidal manifestation of Graves' disease with unrevealed pathogenesis. Interleukin 29 (IL-29) is a relatively newly discovered inflammatory cytokine. Thus, the aim of this study was to evaluate the relationship between IL-29 and Graves' orbitopathy (GO) in euthyroid patients. Thirty-one euthyroid patients with Graves' disease and with active GO [clinical activity score (CAS) ≥ 3/7], seventeen euthyroid patients with GD but without GO, and seventy-two healthy control subjects (CS) matched for age and gender were enrolled in the study. The following parameters were evaluated in every participant: thyroid-related hormones and autoantibodies and inflammatory markers (white blood cells, hsCRP). ELISA assay was applied to measure the concentration of IL-29. We found higher level of IL-29 in GO group in comparison with CS [165 (133-747) vs. 62 (62-217) pg/mL, p < 0.001]. Furthermore, participants in the subgroup with GD with GO as compared with GD without GO had higher concentration of IL-29 [165 (133-747) vs. 62 (62-558) pg/mL, p = 0.031]. The ROC analysis for IL-29 revealed IL-29 cut-off of 105 pg/mL (sensiti...Continue Reading

References

Mar 17, 2000·The Journal of Clinical Endocrinology and Metabolism·Y HiromatsuY Inoue
Jan 1, 1950·Cancer·W J YOUDEN
Feb 27, 2008·European Journal of Endocrinology·Luigi BartalenaUNKNOWN European Group on Graves' Orbitopathy (EUGOGO)
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Jul 27, 2010·Cytokine & Growth Factor Reviews·Katrin WitteKerstin Wolk
Sep 27, 2013·Science Translational Medicine·Kerstin WolkRobert Sabat
Jun 10, 2015·Autoimmunity·Andréa Tavares DantasMaira Galdino da Rocha Pitta
Jul 2, 2015·Journal of Leukocyte Biology·Rik A de GroenAndré Boonstra
Jul 23, 2015·Immunity·Helen M LazearMichael S Diamond
Aug 19, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Donghua XuXiaodong Wang
Mar 12, 2016·Expert Review of Clinical Pharmacology·Marek Ruchała, Nadia Sawicka-Gutaj
Apr 22, 2016·European Thyroid Journal·Luigi BartalenaUNKNOWN European Group on Graves' Orbitopathy (EUGOGO)
Jun 28, 2016·The Lancet. Diabetes & Endocrinology·Wilmar M Wiersinga
Jul 20, 2016·Mediators of Inflammation·Lingxiao XuFang Wang
Oct 27, 2016·Scandinavian Journal of Immunology·J H JungS J Choi
Sep 14, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J da SilvaR Louis
Sep 18, 2016·Critical Reviews in Oncology/hematology·Noah E KelmYujiang Fang
Nov 1, 2016·The New England Journal of Medicine·Terry J Smith, Laszlo Hegedüs
May 4, 2017·The New England Journal of Medicine·Terry J SmithRaymond S Douglas
Aug 26, 2017·International Journal of Endocrinology·Rong-Hua SongJin-An Zhang
Jul 3, 2018·Endocrine, Metabolic & Immune Disorders Drug Targets·Carlos A CanasGabriel J Tobon
Apr 3, 2019·Endokrynologia Polska·Meng ShuaiJin-An Zhang
Jul 4, 2019·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Kaijun LiChao Ma
Jan 16, 2020·Journal of Clinical Medicine·Bogusz FalkowskiDorota Zozulinska-Ziolkiewicz

❮ Previous
Next ❯

Citations

Jul 6, 2021·Mediators of Inflammation·Michał OlejarzMarek Ruchała

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

Statistica

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.