Evaluation of immunological responses to a glycoprotein G deficient candidate vaccine strain of infectious laryngotracheitis virus

Vaccine
Joanne M DevlinCarol A Hartley

Abstract

Infectious laryngotracheitis virus (ILTV), an alphaherpesvirus, causes severe respiratory disease in poultry. Glycoprotein G (gG) is a virulence factor in ILTV. Recent studies have shown that gG-deficient ILTV is an effective attenuated vaccine however the function of ILTV gG is unknown. This study examined the function and in vivo relevance of ILTV gG. The results showed that ILTV gG binds to chemokines with high affinity and inhibits leukocyte chemotaxis. Specific-pathogen-free (SPF) chickens infected with gG-deficient virus had altered tracheal leukocyte populations and lower serum antibody levels compared with those infected with the parent virus. The findings suggest that the absence of chemokine-binding activity during infection with gG-deficient ILTV results in altered host immune responses.

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Citations

Apr 25, 2013·Avian Pathology : Journal of the W.V.P.A·Alireza MahmoudianGlenn F Browning
May 31, 2013·Avian Pathology : Journal of the W.V.P.A·Mauricio J C CoppoJoanne M Devlin
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Jun 11, 2016·The Journal of General Virology·Maricarmen GarciaG H Schneiders
Mar 28, 2017·Avian Pathology : Journal of the W.V.P.A·Dinidu S WijesurendraGlenn F Browning
May 26, 2017·PLoS Pathogens·Víctor González-MotosAbel Viejo-Borbolla
May 18, 2019·The Journal of General Virology·Julia SchädlerNina Wolfrum
Nov 17, 2017·Journal of Immunoassay & Immunochemistry·Madelyn KrunkoskyRobert M Gogal

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