Evaluation of immunotoxicity induced by propoxure in C57Bl/6 mice

International Immunopharmacology
Z M HassanE Zabihi Neishabouri

Abstract

Insecticides are important candidates for immunotoxicology tests in order to assess the 'No Observable Adverse Effect Level' (NOAEL). Propoxure (PPX), as a carbamate household insecticide, has been used for several decades around the world in agriculture. However, there has been no clear investigation on its immunotoxic potentials. In this study, as Tier I of immunotoxicological screening tests, we examined the effects of subacute exposure to intraperitoneally (i.p.) administered PPX, at doses of 10, 2, and 0.2 mg/kg, on C57Bl/6 female mice. After 28 days administration of PPX, the treated animals were sacrificed and peripheral blood samples were collected. Then spleen (SP), thymus (TM), and bone marrow were collected and weighed. Functional tests including SRBC-hemagglutination (HA), plaque-forming colony assay (PFC), and delayed type hypersensitivity (DTH) response to SRBCs were performed. Furthermore, spleen T-cell phenotype (CD4/CD8) was also determined. Results showed that high doses of PPX could not only produce histopathological changes in TM and SP but also suppress humoral response to antigen (SRBCs). PPX at medium doses (2 mg/kg) did not show histopathological changes in TM or SP but increased the humoral response to ...Continue Reading

References

Oct 1, 1992·International Journal of Immunopharmacology·O HajouiK Krzystyniak
May 1, 2001·The Science of the Total Environment·H W Vohr, C Rühl-Fehlert
Sep 6, 2001·Ecotoxicology and Environmental Safety·O SirokiI Dési
Aug 22, 2002·International Immunopharmacology·Ladan Ghotbi, Zuhair Hassan
Dec 25, 2002·Journal of Ethnopharmacology·A B GokhaleM N Saraf

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Citations

Mar 8, 2013·Environmental Toxicology and Pharmacology·Prarabdh C BadgujarGauri A Chandratre
Mar 30, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B RiahiG Karimi
Jan 10, 2008·International Immunopharmacology·Mohammad FararjehShtaywy Abdalla
May 13, 2017·Environmental Science and Pollution Research International·Eman I DrazMohamed A Elomary
Feb 9, 2011·Journal of Immunotoxicology·Bamdad RiahiGholamreza Karimi

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