Evaluation of in vitro anti-inflammatory and antibacterial potential of Crescentia cujete leaves and stem bark

BMC Research Notes
Mst Shahnaj ParvinMd Ekramul Islam

Abstract

The various parts of Cresecentia cujete have some important biological activities. In folklore medicine leaves are used to treat hematomas, tumors and hypertension. Fruit decoction is used to treat diarrhea, stomachaches, cold, bronchitis, cough, asthma, and urethritis. The present study was designed to explore the anti-inflammatory and antibacterial potential of C. cujete leaves and stem bark. Anti-inflammatory activity was evaluated by in vitro human red blood cell (HRBC) membrane stabilization method and antibacterial activity by disc diffusion method. In vitro anti-inflammatory activity was evaluated by human red blood cell (HRBC) membrane stabilization method while in vitro antibacterial activity was evaluated using cultures of Escherichia coli and Staphylococcus aureus by disc diffusion method. Total phenolic (TPC) and total flavonoid contents (TFC) of the crude extract and fractions were also determined by Folin-Ciocalteu's phenol reagent and by aluminium chloride method, respectively. The crude ethanol extract (CEE) of leaves and bark (concentration of each 1.0 mg/ml) demonstrated strong membrane stabilizing activity (53.86 and 61.85% protection, respectively), whereas their chloroform fractions (CHF) revealed moderate ...Continue Reading

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Citations

Aug 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohamed Nadjib BoukhatemShaker A Mousa
Jul 27, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Fatai Oladunni Balogun, Saheed Sabiu
Jul 3, 2021·Journal of Basic and Clinical Physiology and Pharmacology· TeodhoraIka Maruya Kusuma
Mar 10, 2020·Journal of Ethnopharmacology·Vincent RoumyThierry Hennebelle

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