Evaluation of In Vitro-based simulations of toluene uptake and metabolism in rats

Toxicology in Vitro : an International Journal Published in Association with BIBRA
J DeJongh, B J Blaauboer

Abstract

The uptake of toluene in the rat from a closed exposure chamber was simulated with a physiologically based pharmacokinetic (PB-PK) model. Six different parameter sets for toluene biotransformation in vitro were subsequently substituted in the model while keeping all other model parameters constant. Simulations of toluene uptake and metabolism based on these six in vitro-derived biotransformation parameter sets were compared with two empirical in vivo data sets on the decrease of toluene concentrations in closed exposure chambers. It was observed that simulations based on in vitro-derived biotransformation parameters gave similar or better results than simulations across these two in vivo data sets. It is concluded that the results from most studies on toluene biotransformation in vitro resulted in adequate simulations of uptake and metabolism of toluene in vivo. These results support earlier findings on application of in vitro techniques to derive parameters for PB-PK models.

References

Apr 1, 1979·Toxicology and Applied Pharmacology·A Sato, T Nakajima
Jul 1, 1990·Toxicology Letters·K J PurcellC C Travis
Mar 15, 1989·Toxicology and Applied Pharmacology·M L GargasM E Andersen
Dec 1, 1986·Toxicology and Applied Pharmacology·M L GargasH J Clewell
Jul 1, 1985·Toxicology Letters·M WallénM Byfält Nordqvist
Nov 1, 1981·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R L HilderbrandL J Jenkins
Apr 1, 1995·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·A E Smith, J S Evans

❮ Previous
Next ❯

Citations

May 24, 2001·Progress in Cardiovascular Nursing·E J Bridges, S L Woods

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.