PMID: 15348796Sep 7, 2004Paper

Evaluation of in vitro bioactivity and biocompatibility of Bioglass-reinforced polyethylene composite

Journal of Materials Science. Materials in Medicine
J HuangW Bonfield

Abstract

The bioactivity and biocompatibility of Bioglass-reinforced high-density polyethylene composite (Bioglass/HDPE) have been evaluated in simulated body fluid (SBF) and by in vitro cell culture, respectively. The formation of a biologically active hydroxy-carbonate apatite (HCA) layer on the composite surface after immersion in SBF was demonstrated by thin-film X-ray diffraction, infrared spectroscopy and scanning electron microscopy, indicating the in vitro bioactivity of Bioglass/HDPE composites. The HCA layer was formed on the 40 vol% composite surface within 3 days immersion in SBF at a formation rate comparable to those on bioactive glass-ceramics, showing that in vitro bioactivity could be obtained in a composite. Furthermore, the composite was biocompatible to primary human osteoblast-like cells. In comparison with unfilled HDPE and tissue culture plastic control, a significant increase in cellular metabolic activity was found on the composite. Therefore, Bioglass/HDPE composites have a promising biological response as a potential implant material.

Citations

Feb 6, 2007·Journal of Materials Science. Materials in Medicine·Andrew HartMatthew J Dalby
Jan 11, 2008·Journal of Biomedical Materials Research. Part a·J HuangW Bonfield
Jul 2, 2010·Journal of the Royal Society, Interface·K E Tanner
Jul 8, 2017·Journal of Biomedical Materials Research. Part a·M RizwanW J Basirun

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