Evaluation of in vivo efficacy and toxicity of prednisolone-loaded hydrogel-based drug delivery device

International Journal of Pharmaceutical Investigation
Amit Kumar DeArup Mukherjee

Abstract

Drugs prescribed for the treatment of moderate to severe inflammatory bowel disease (IBD) are associated with number of side effects. Targeted drug delivery is essential for the treatment of inflammatory bowel disease in order to increase efficacy and reduce toxicity. The established delivery system is designed on enzyme and time-based release of poorly soluble prednisolone, a drug of choice for the treatment of moderate to severe inflammatory bowel disease. Their pharmacological evaluation was done in 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced model of colitis in rat. The drug was administered once daily for 3 consecutive days. Visible severity of colitis, tissue to bodyweight ratio, tissue histology along with nitric oxide (NO), malondialdehyde (MDA) and myeloperoxidase (MPO) activity of colonic tissue were studied to estimate the efficacy of the drug-loaded delivery system. The highest efficacy was observed for formulation in which Eudragit RS100 (EU) was used along with guar gum (GG) in a ratio 2:5 for the preparation of delivery device. An effective recovery was observed from the study of tissue histology of animals treated with the drug-loaded optimized formulation and the biochemical parameters supported it. The...Continue Reading

Citations

Mar 19, 2016·Journal of Pharmaceutics·Siddhartha MaityBiswanath Sa
May 17, 2018·Journal of Biomaterials Science. Polymer Edition·Hye Ri LeeJin Ho Lee
Oct 2, 2015·Beilstein Journal of Nanotechnology·Nina JeliazkovaEgon Willighagen

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Methods Mentioned

BETA
infrared
x-ray
atomic force microscopy
MDA
AFM

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