PMID: 9185029Apr 1, 1997Paper

Evaluation of indapamide 1.25 mg once daily in elderly patients with mild to moderate hypertension

Journal of Human Hypertension
R FiddesJ Codispoti

Abstract

The objective of this study was to evaluate the safety and efficacy of indapamide 1.25 mg once daily as monotherapy in elderly patients (65 years and older) with mild to moderate essential hypertension. Two hundred and seventy-nine (279) elderly patients were enrolled in a washout period, during which patients received single-blind placebo for 4 weeks. Patients demonstrating supine diastolic pressures between 95 mm Hg and 114 mm Hg at the end of the 4-week placebo washout period were entered into the 8-week double-blind treatment period. Two hundred and four (204) patients qualified for the study and were randomized to the double-blind treatment; 103 patients received indapamide 1.25 mg and 101 patients received placebo for 8 weeks. Overall, 177 patients (92 indapamide and 85 placebo) completed the study. The primary efficacy criterion was the mean change in supine diastolic blood pressure (DBP) from double-blind baseline to the end of 8 weeks of therapy. By week 8 of the double-blind treatment period, indapamide 1.25 mg produced a statistically significant (P = 0.0037) decrease in supine DBP of 8.2 mm Hg compared to a decrease of 5.3 mm Hg produced in the placebo group. Additionally, indapamide 1.25 mg was statistically (P = 0...Continue Reading

Citations

Jun 26, 2007·Orvosi hetilap·Valentin BrodszkyLászló Gulácsi
Mar 5, 2010·Journal of Cardiovascular Pharmacology and Therapeutics·Hirotsugu YamadaMasataka Sata
May 3, 2002·Journal of Human Hypertension·A J Reyes
Nov 9, 2005·Expert Review of Neurotherapeutics·Mark F Lew
Apr 9, 2001·Aging : Clinical and Experimental Research·A GottliebD Gottlieb
May 30, 2014·The Cochrane Database of Systematic Reviews·Vijaya M MusiniJames M Wright
Mar 12, 2020·Journal of General Internal Medicine·Jill J HallJohn-Michael Gamble

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