Abstract
Iron deficiency anemia (IDA) and beta-thalassemia trait (beta-TT) are the most common microcytic anemia. Kinds of discrimination indices have been established as simple, fast, and inexpensive means since 1970s. This study evaluates the validity of 12 indices in differentiation between IDA and beta-TT for Chinese children. The 12 discrimination indices were red blood cell (RBC) count, RBC distribution width, Mentzer Index, Green and King Index, RBC distribution width Index, England and Fraser Index, Shine and Lal Index, Srivastava Index, Ricerca Index, Ehsani Index, Sirdah Index, and Huber-Herklotz-Index. A total of 300 children (beta-TT, n=127 and IDA, n=173) were enrolled in the study. We calculated the sensitivity and specificity, positive and negative predictive values, and Youden's index for each index. We also established new cut-off values by receiver operating characteristic curves. Green and King Index showed the highest reliability, as it had the largest area under the curve (AUC=0.947), whereas Srivastava Index and Shine and Lal Index showed the lowest reliability (AUC=0.679 and 0.532, respectively). We concluded Green and King Index, Ricerca Index, and England and Fraser Index could be used in discrimination between ...Continue Reading
References
Mar 26, 1977·Lancet·I Shine, S Lal
Nov 1, 1976·American Journal of Clinical Pathology·G G KleeM B O'Sullivan
Jan 1, 1987·Acta Haematologica·B F OdermattJ R Rüttner
Jan 1, 1987·Acta Haematologica·H R MartiW Bürgi
Mar 3, 1973·Lancet·J M England, P M Fraser
Apr 21, 1973·Lancet·R E Rewell
Apr 21, 1973·Lancet·W C Mentzer
Jul 8, 1999·The New England Journal of Medicine·N F Olivieri
Dec 18, 2001·The Netherlands Journal of Medicine·A van TellingenW L Vasmel
Oct 3, 2002·Clinical and Laboratory Haematology·I El-AgouzaM Sirdah
Nov 8, 2002·Pediatrics International : Official Journal of the Japan Pediatric Society·Aysin DemirAbdurrahman Kara
May 1, 1953·Australasian Annals of Medicine·C R BLACKBURN
Apr 22, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·José F A Noronha, Helena Z W Grotto
Dec 15, 2006·Journal of Tropical Pediatrics·Suad M AlFadhliDoa'a AlKhaldi
Jan 25, 2007·Journal of Postgraduate Medicine·N KakkarR Wadhawan
Apr 11, 2007·European Journal of Haematology·Cengiz BeyanAhmet Ifran
May 4, 2007·Annals of Hematology·George NtaiosStiliani Alexiou-Daniel
Jun 19, 2007·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Athanasia AgorastiDespina Konstantinidou
Sep 11, 2007·International Journal of Laboratory Hematology·C CeylanE Ozdemir
Sep 19, 2007·American Journal of Clinical Pathology·Dinesh A RathodPranay Shah
Nov 22, 2007·European Journal of Radiology·Mehran KarimiMurtaza Rashid
Feb 21, 2008·American Journal of Clinical Pathology·Alexandra M HarringtonSteven H Kroft
Feb 26, 2008·Journal of Postgraduate Medicine·M KhurramZ Hasan
Feb 26, 2008·Journal of Postgraduate Medicine·G Ntaios, A Chatzinikolaou
May 1, 2008·International Journal of Laboratory Hematology·M SirdahR Al Haddad
May 28, 2008·International Journal of Laboratory Hematology·G Ntaios, A Chatzinikolaou
May 31, 2008·International Journal of Laboratory Hematology·E Urrechaga
Jul 31, 2008·British Journal of Haematology·George Ntaios, Anastasia Chatzinikolaou
Sep 18, 2008·Hematology·J Eivazi-ZiaeiR Soltanpour
Feb 14, 2009·The Journal of International Medical Research·V OkanM Pehlivan
Feb 21, 2009·American Journal of Clinical Pathology·Claude Owen Burdick
Mar 10, 2009·International Journal of Laboratory Hematology·G Ntaios, A Chatzinikolaou
Jul 8, 2009·Pakistan Journal of Biological Sciences : PJBS·M A EhsaniA Rashidi
Oct 22, 2009·Hematology·George Ntaios
Citations
Jun 16, 2015·Hemoglobin·Soontharee PlengsureeSakorn Pornprasert
Jan 7, 2014·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yang-Che WuAndy Sun
Oct 22, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yi-Ping WangAndy Sun
Jan 17, 2013·Hematology·Januária Fonseca MatosMaria das Graças Carvalho
Jul 6, 2014·Hemoglobin·Sakorn PornprasertChatpat Kongpan
Aug 8, 2012·Pediatric Hematology and Oncology·Burçin NalbantoğluBurcu Özdilek
Jun 10, 2017·Hemoglobin·Sakorn PornprasertUraiporn Panyachadporn
Sep 22, 2017·Laboratory Medicine·Abdul Hafeez KandhroPornlada Nuchnoi
Sep 29, 2018·Lab on a Chip·Lieshu TongZachary J Smith
Feb 14, 2015·PloS One·Tzu-Chuan HuangJia-Hong Chen
Apr 26, 2018·Ciência & saúde coletiva·Hercilio Paulino AndréSilvia Eloiza Priore
Aug 15, 2013·International Journal of Laboratory Hematology·A E AsbergA Asberg
Aug 19, 2016·PloS One·Tania MannanRubhana Raqib
May 9, 2012·Journal of Thrombosis and Haemostasis : JTH·J MellerT V Byzova
Nov 5, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Johannes J M L HoffmannUrko Aguirre
Mar 16, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Chaima A SahliTaieb Messaoud
Jun 17, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Lorenz RischMartin Risch
Jun 27, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Chaima Abdelhafidh SahliTaieb Messaoud
Sep 7, 2017·Scientific Reports·Lieshu TongZachary J Smith
Apr 7, 2019·Annals of Hematology·Xiaozhe LinYongni Wang
Dec 11, 2019·Scientific Reports·Mina JahangiriAmal Saki Malehi
Aug 10, 2020·Journal of Pediatric Hematology/oncology·Natthawadee NantaPimlak Charoenkwan
Oct 27, 2020·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Mudita BhargavaPoonam Gupta
Oct 1, 2019·Journal of Pediatric Hematology/oncology·Yeter Düzenli KarÖzcan Bör