Evaluation of individual low-dose dexamethasone suppression test patterns in naturally occurring hyperadrenocorticism in dogs

Journal of Veterinary Internal Medicine
Michael BennaimCarmel T Mooney

Abstract

Dogs with hyperadrenocorticism (HAC) may be more mildly affected at the time of diagnosis today, which could influence the prevalence of associated clinical and clinicopathological abnormalities and diagnostic test performance. Different low-dose dexamethasone suppression test (LDDST) result patterns have not been evaluated individually. To assess the current features of HAC and evaluate if the diagnostic test performance of individual LDDST result patterns differ. One hundred and twenty-three dogs undergoing investigation for HAC. Retrospective evaluation of dogs in which a LDDST was performed and HAC confirmed or excluded by alternative means. Cases with basal cortisol concentrations (t0 ) < 1 μg/dL were excluded. Each LDDST result was classified as (a) complete suppression (t3 and t8  < 1 μg/dL), (b) lack of suppression (t3 and t8  > 1 μg/dL and both > 50% t0 ), (c) partial suppression (t3 and t8  > 1 μg/dL but either < 50% t0 ), (d) escape (t8  > 1 μg/dL and t3  < 1 μg/dL) or (e) inverse (t3  > 1 μg/dL and t8  < 1 μg/dL) pattern. Fifty-nine (48%) dogs were diagnosed with HAC and 64 (52%) with non-adrenal illness. Hyperadrenocorticism cases had similar clinicopathological abnormalities compared to previous reports. Sensitivi...Continue Reading

References

May 1, 1991·Journal of Veterinary Internal Medicine·P P Kintzer, M E Peterson
Jan 1, 1991·Journal of Veterinary Internal Medicine·C E Reusch, E C Feldman
Feb 20, 1988·The Veterinary Record·A RijnberkJ A Mol
Jul 1, 1984·The Veterinary Clinics of North America. Small Animal Practice·M E Peterson
Jun 11, 1994·BMJ : British Medical Journal·D G Altman, J M Bland
Jul 1, 1997·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·A K SinghD Spassova
Sep 26, 2001·The Veterinary Clinics of North America. Small Animal Practice·E N Behrend, R J Kemppainen
Jun 8, 2002·Journal of the American Veterinary Medical Association·Ellen N BehrendMark E Peterson
Apr 10, 2003·Journal of Veterinary Internal Medicine·T L GiegerG Dank
May 24, 2005·Journal of the American Veterinary Medical Association·Ellen N BehrendRobert J Kemppainen
Jul 11, 2006·Journal of the American Animal Hospital Association·Dolores Perez AlenzaCarlos Melian
Apr 3, 2012·Journal of Veterinary Internal Medicine·P M Y SmetsS Daminet
Oct 4, 2012·Journal of the American Animal Hospital Association·Jennifer L FrankotBarbara E Powers
Oct 12, 2013·Journal of Veterinary Internal Medicine·E N BehrendJ C Scott-Moncrieff

❮ Previous
Next ❯

Citations

Nov 5, 2020·Journal of Veterinary Internal Medicine·Beatriz MendozaRodolfo Oliveira Leal
Mar 18, 2021·Veterinary Clinical Pathology·Florian K ZeugswetterIlse Schwendenwein
Jun 4, 2021·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Guido LinariFederico Fracassi
Jul 23, 2021·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Jérémie Korchia, Kathleen P Freeman
Jul 2, 2021·The Journal of Small Animal Practice·B A McKenzie

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.