PMID: 7437237Sep 1, 1980Paper

Evaluation of indoramin added to oxprenolol and bendrofluazide as a third agent in severe hypertension

British Journal of Clinical Pharmacology
A J MarshallD W Barritt

Abstract

1 Indoramin, an alpha-adrenoreceptor blocking agent has been given as a third agent to patients with severe hypertension treated with adequate doses of a beta-adrenoceptor blocking drug and a thiazide diuretic. 2 A further fall in blood pressure followed the addition of indoramin. With 75 mg twice daily this was on average a fall of 12% of mean arterial pressure in the supine position, 16% standing an 17% after exercise. 3 The rise in blood pressure caused by isometric exercise was not altered by indoramin. 4 Indoramin slowed the heart rate. On 75 mg twice daily the reduction was 14% at rest and 19% after exercise. 5 Side effects of indoramin were sedation, sleep disturbance and vivid dreams.

References

Aug 1, 1978·The Journal of Pharmacy and Pharmacology·K F Rhodes, J F Waterfall
Jun 1, 1979·Clinical Pharmacology and Therapeutics·G S StokesE P MacCarthy
Jun 1, 1976·British Journal of Clinical Pharmacology·G H DraffanC T Dollery
Aug 1, 1977·British Heart Journal·D W Barritt, A J Marshall
Oct 18, 1975·British Medical Journal·J C PetrieJ A Lewis
Aug 1, 1973·The Journal of Pharmacy and Pharmacology·D H Variava, P Turner
Dec 1, 1973·European Journal of Clinical Pharmacology·P J LewisC T Dollery
May 1, 1972·Clinical Pharmacology and Therapeutics·R B RoydsJ D Lockhart

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Citations

Apr 1, 1989·Cardiovascular Drugs and Therapy·P A van Zwieten

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