Evaluation of infectious and non-infectious complications in patients with primary immunodeficiency

Central-European Journal of Immunology
Saeed BazregariAsghar Aghamohammadi

Abstract

Primary immunodeficiency diseases (PIDs) are a heterogeneous group of genetic immune disorders. PID patients suffer from a variety of complications. The aim of this study was to determine the infectious and non-infectious complications among PID patients. This retrospective cohort study was performed on recorded data of 202 PID patients who were diagnosed with eight major categories: common variable immunodeficiency (CVID), X-linked agammaglobulinemia, hyper-IgM syndrome, hyper IgE syndrome, chronic granulomatous disease (CGD), ataxia telangiectasia, hereditary angioedema and leukocyte adhesion deficiency. For all patients, infectious and non-infectious manifestations and laboratory data were collected in a comprehensive questionnaire. Infectious complications were more frequent than non-infectious complications. Pneumonia and otitis media were the main infectious problems in PID patients, especially in patients with antibody deficiencies. Among the non-infectious complications, splenomegaly and hepatomegaly were the most common complications in PID patients, and were more commonly seen in CGD patients than others. Splenomegaly, hepatomegaly and autoimmunity were the most common findings in CVID patients. A significant correlat...Continue Reading

Citations

Aug 29, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Marzieh TavakolAsghar Aghamohammadi
Sep 27, 2018·Frontiers in Pediatrics·Jose Antonio Tavares de AlbuquerqueAntonio Condino-Neto
Jun 2, 2020·Frontiers in Immunology·Denise Helena Boton PereiraLuiz Euribel Prestes-Carneiro
Jul 14, 2020·Frontiers in Immunology·Marcin ZiętkiewiczKarina Jahnz-Różyk
Jul 13, 2020·Current Allergy and Asthma Reports·Maine L D BardouAnete S Grumach
Oct 31, 2018·Frontiers in Immunology·Lisanne M A JanssenEsther de Vries
Feb 9, 2021·The Journal of Allergy and Clinical Immunology·Jovanka R KingLennart Hammarström
May 31, 2021·Journal of Clinical Immunology·Asghar AghamohammadiHassan Abolhassani

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