PMID: 4043199Jan 1, 1985

Evaluation of infusion regimens for thiopentone as a primary anaesthetic agent

European Journal of Clinical Pharmacology
D P CrankshawD J Morgan

Abstract

Several multi-stage infusion regimens and a computer controlled exponentially decreasing infusion regimen were evaluated in twelve patients undergoing head and neck surgery or neurosurgery. Thiopentone dosage was based on the mean of pharmacokinetic parameter values from the literature and adjusted for each patient's lean body mass in order to rapidly achieve a predetermined plasma thiopentone concentration of 15 or 20 micrograms/ml in the period following the initial bolus dose to induce anaesthesia. Anaesthesia was satisfactory in all cases. Plasma thiopentone concentrations were maintained between 10-20 micrograms/ml during infusion in the five patients who received either a four or five stage infusion and in the six patients who received the exponential infusion, but not in the single patient who received a two-stage infusion. The mean recovery time was 111 min. The plasma concentrations of total and unbound thiopentone at awakening showed little intersubject variability, despite considerable differences in total dose and duration of infusion, suggesting the absence of acute tolerance to the drug. Plasma clearance of total thiopentone correlated strongly with calculated lean body mass and to a lesser extent with total body ...Continue Reading

References

Sep 1, 1978·Critical Care Medicine·G C CarlonA Turnbull
Aug 1, 1979·Journal of Pharmaceutical Sciences·L Z Benet, R L Galeazzi
Feb 1, 1978·Anaesthesia and Intensive Care·D P Crankshaw, J Allt-Graham
Sep 1, 1978·Anesthesiology·K E Becker
Sep 1, 1978·Anesthesiology·K E Becker, A S Tonnesen
Jul 19, 1976·JAMA : the Journal of the American Medical Association·D J GreenblattJ S Harmatz
Oct 1, 1974·Clinical Pharmacology and Therapeutics·J G Wagner
Oct 1, 1968·European Journal of Pharmacology·E Krüger-Thiemer
Jun 1, 1969·British Journal of Anaesthesia·N L Wulfsohn, C W Joshi
Dec 1, 1983·Acta Anaesthesiologica Scandinavica·J H ChristensenJ A Jansen
Aug 1, 1983·Anesthesiology·G PandeleP Duvaldestin
Jan 1, 1982·European Journal of Drug Metabolism and Pharmacokinetics·B VandelD Blum
May 1, 1982·Journal of Pharmaceutical Sciences·A B Straughn
Oct 1, 1982·Journal of Pharmacokinetics and Biopharmaceutics·K K Chan, M Gibaldi
Sep 1, 1980·Clinical Pharmacology and Therapeutics·S E TsueiJ Thomas
Aug 1, 1980·Anesthesiology·D R StanskiS M Kalman
Oct 1, 1980·British Journal of Anaesthesia·W TonerJ W Dundee
Oct 1, 1980·British Journal of Anaesthesia·J H HengstmannJ Schüttler
Sep 1, 1980·British Journal of Anaesthesia·J H ChristensenJ A Jansen
Apr 1, 1981·Clinical Pharmacology and Therapeutics·D G ShandE L Pritchett
Aug 1, 1956·British Journal of Anaesthesia·R D DRIPPSH L PRICE

Citations

May 31, 2013·European Journal of Clinical Pharmacology·Amélie MarsotNicolas Simon
Mar 1, 1989·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M T DachowskiE A Dolan
Jun 1, 1994·Journal of Critical Care·M WeissP Wernet
Nov 1, 1986·British Journal of Clinical Pharmacology·D J MorganS P Ziccone
Jul 1, 1997·Clinical Pharmacology and Therapeutics·H RussoS Urien
Aug 1, 1995·Anesthesia and Analgesia·A KurzA R Bjorksten
Feb 1, 1987·Anaesthesia and Intensive Care·D P Crankshaw
Oct 30, 2001·Anesthesia and Analgesia·M MokhtaraniD I Sessler
Oct 17, 1988·The Medical Journal of Australia·D P Crankshaw

Related Concepts

Parenteral Infusion
Mathematics
Regression Analysis
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