Evaluation of inner retinal layers with optic coherence tomography in vigabatrin-exposed patients

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Betül TuğcuDilek Ataklı

Abstract

In order to reveal the underlying retinal pathology leading to dysfunction in vigabatrin-exposed patients, we aimed to evaluate the inner retinal layers encompassing ganglion cell complex (GCC) layer and inner plexiform layer with new generation optic coherence tomography (OCT). Fourteen patients with epilepsy and exposure to vigabatrin and 12 clinically normal individuals, constituting the control group, were included. Retinal images were obtained using spectral-domain OCT (Optovue RTVue Fourier domain). Nasal and superior quadrants of retinal nerve fiber layer (RNFL) were found to be significantly lower in the patient group compared to the controls (p < 0.01). No significant difference was shown in the thickness of GCC layer (p > 0.05). Foveal thickness was significantly higher in the patient group (p: 0.006), but no significant difference was found in perifoveal and parafoveal regions between groups (p > 0.05). The thickness of RNFL was found to be lower in vigabatrin-exposed patients without any reduction in GCC layer in the macular region. However, foveal thickness was found to be significantly higher compared to perifoveal and parafoveal macular regions in vigabatrin-exposed patients. In conclusion, OCT revealed reduced t...Continue Reading

References

Jan 18, 1997·BMJ : British Medical Journal·T EkeM C Lawden
Jun 1, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·J RavindranH Waddy
Jul 27, 2001·Ophthalmology·S G CouplandT M Ross
May 4, 2004·Annals of Neurology·Agnès DubocSerge Picaud
Aug 27, 2004·Epilepsia·Yukitoshi IzumiLiu Lin Thio
Mar 1, 2006·Investigative Ophthalmology & Visual Science·John M WildPhilip E M Smith
Apr 17, 2008·The European Journal of Neuroscience·Qing-Ping WangSerge Picaud
Jan 27, 2009·Ophthalmology·Charlotte LawthomJohn M Wild
Mar 24, 2009·The British Journal of Ophthalmology·G VizzeriL M Zangwill
Aug 4, 2009·The British Journal of Psychiatry : the Journal of Mental Science·UNKNOWN Cross-Disorder Phenotype Group of the Psychiatric GWAS ConsortiumAnita Thapar
Feb 6, 2010·Molecular and Cellular Neurosciences·Firas JammoulSerge Picaud
Jan 20, 2011·Annals of Neurology·Lisa M ClaytonSanjay M Sisodiya
Apr 24, 2016·Pediatric Neurology·Noémie Hébert-LalondeDave Saint-Amour

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Citations

Dec 28, 2017·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Rod Foroozan
Jan 13, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ilaria Di Donato, Antonio Federico

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