PMID: 8968447Dec 1, 1996Paper

Evaluation of inpatient depot antipsychotic prescribing

The Annals of Pharmacotherapy
D J PabisM L Crismon

Abstract

To assess the use of fluphenazine decanoate and haloperidol decanoate in an inpatient setting. A prospective observational study conducted over a 3-month period. A 400-bed state psychiatric hospital. The psychiatric pharmacy staff evaluated the medical records and new orders of 30 consecutive patients receiving depot antipsychotic formulations using a detailed evaluation form and the hospital pharmacy computer database. Criteria for evaluation were derived from the medical literature and product information, and included the following areas: diagnosis, stabilization on a short-acting form of the antipsychotic, appropriateness of dosage conversion to depot therapy, concomitant administration of short-acting antipsychotics (and duration of concomitant medications), and plasma concentration monitoring. Only 7 patients (23%) received what would be considered optimal depot antipsychotic therapy. These patients were receiving a stable dosage of a short-acting antipsychotic prior to conversion to depot therapy (i.e., > or = 7 d), received optimal dose conversion to a depot form, and received optimum overlap with a short-acting preparation (i.e., overlap < or = 7 d with fluphenazine HCI and 7-30 d with haloperidol HCI). When length of ...Continue Reading

Citations

Aug 26, 2003·American Journal of Medical Quality : the Official Journal of the American College of Medical Quality·Richard R OwenBrenda M Booth

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