Evaluation of insulin sensitivity and glucose effectiveness during a standardized breakfast test: comparison with the minimal model analysis of an intravenous glucose tolerance test

Metabolism: Clinical and Experimental
Ikram AloulouJacques Mercier

Abstract

There is a need for reliable measurements of insulin sensitivity (SI) simpler than the euglycemic hyperinsulinemic clamp or the intravenous glucose tolerance test (IVGTT), which could be used when the simpler surrogates based on fasting insulin (Ib) and glucose (Gb) lose their validity. Several evaluations of SI derived from oral glucose tolerance test (OGTT) or its physiologic form, the standardized breakfast test (SBT), have been proposed. We aimed at determining which SBT-derived measurements of SI give the best prediction of the values obtained with the minimal model analysis of an IVGTT. Twenty-eight subjects (23 females and 5 males; age, 44.3+/-0.6 years) with a wide range of glucose tolerance randomly underwent a hyperglucidic SBT and an IVGTT with minimal model analysis. Correlations of 35 indices (converted if appropriated into similar units) with IVGTT-derived SI were calculated, and the accuracy of the empiric formulas obtained with the 11 best predictions were evaluated with Bland-Altman plots. Subjects covered all the spectrum of SI between 0.19 and 21.3 min-1/(microU.mL-1)x10(-4). Eight procedures yielded satisfactory predictions of minimal model SI: (1) SI (from Matsuda's composite index)=-1.24+65/(IbGbImGm)-0.5;...Continue Reading

References

Dec 1, 1990·The Journal of Clinical Endocrinology and Metabolism·S WelchL S Phillips
Oct 1, 1989·The Journal of Clinical Endocrinology and Metabolism·G TamburranoA Lala
Jan 1, 1985·Endocrine Reviews·R N BergmanM Ader
Dec 1, 1981·Diabetes·A Lev-Ran, R W Anderson
May 1, 1998·Molecular Genetics and Metabolism·F BelfioreG Volpicelli
Jun 22, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A AvignonL Monnier
Aug 19, 2000·International Journal of Sports Medicine·J ManettaC Prefaut
Jun 28, 2002·Diabetes·Christine C JensenUNKNOWN American Diabetes Association GENNID Study Group
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Jérôme ManettaJacques Mercier
Dec 28, 2002·Diabetes Care·UNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Supamai SoonthornpunAlan Geater
May 27, 2004·Diabetes Care·Tara M WallaceDavid R Matthews
Nov 18, 2004·The Journal of Clinical Endocrinology and Metabolism·Frédérique BrandouJacques Mercier

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Citations

Apr 5, 2011·Diabetes Technology & Therapeutics·Kevin C MakiTia M Rains
Aug 13, 2011·Thyroid : Official Journal of the American Thyroid Association·Jorge RezzonicoGabriela Brenta
Jan 6, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jill P CrandallNir Barzilai
Jul 28, 2012·Acta Diabetologica·Shoichiro NagasakaToru Aizawa
Oct 1, 2011·Diabetes Research and Clinical Practice·Kimberly G BrodoviczJacqueline M Dekker
May 4, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K W Ter HorstM J Serlie
Mar 23, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Rena M PollackJill P Crandall
Sep 24, 2010·Ground Water·Matt D Webb, Ken W F Howard
Mar 6, 2021·Frontiers in Molecular Biosciences·Candice TrocméSerge P Bottari
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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