Abstract
To demonstrate the feasibility and to evaluate the tumour control probability (TCP) and normal tissue complication probability (NTCP) of IMRT dose painting using 68Ga-HBED-CC PSMA PET/CT for target delineation in prostate cancer (PCa). 10 patients had PSMA PET/CT scans prior to prostatectomy. GTV-PET was generated on the basis of an intraprostatic SUVmax of 30%. Two IMRT plans were generated for each patient: Plan77 which consisted of whole-prostate IMRT to 77Gy, and Plan95 which consisted of whole-prostate IMRT to 77Gy and a simultaneous integrated boost to the GTV-PET up to 95Gy (35 fractions). The feasibility of these plans was judged by their ability to adhere to the FLAME trial protocol. TCP-histo/-PET were calculated on co-registered histology (GTV-histo) and GTV-PET, respectively. NTCPs for rectum and bladder were calculated. All plans reached prescription doses whilst adhering to dose constraints. In Plan77 and Plan95 mean doses in GTV-histo were 75.8±0.3Gy and 96.9±1Gy, respectively. Average TCP-histo values for Plan77 and Plan95 were 70% (range: 15-97%), and 96% (range: 78-100%, p<0.0001). Average TCP-PET values for Plan77 and Plan95 were 55% (range: 27-82%), and 100% (range: 99-100%, p<0.0001). There was no significa...Continue Reading
Citations
Mar 10, 2018·Future Oncology·Eleni GkikaAnca-Ligia Grosu
May 13, 2018·Radiation Oncology·Sebastian ZschaeckClaus Belka
Jun 6, 2018·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Bettina Beuthien-Baumann, Stefan A Koerber
Jan 7, 2020·The British Journal of Radiology·Tonghe WangXiaofeng Yang
Apr 14, 2018·Radiation Oncology·Constantinos ZamboglouAnca L Grosu
May 3, 2018·Radiation Oncology·Constantinos ZamboglouAnca L Grosu
Dec 4, 2019·Frontiers in Oncology·Mona SplinterNils H Nicolay
Oct 16, 2019·Frontiers in Oncology·Tilman BostelNils H Nicolay
Apr 5, 2020·Cancers·Emily Jungmin HerMartin A Ebert
Sep 18, 2020·Nuclear Medicine Communications·Ajay SasidharanPalak Popat
Dec 29, 2020·Frontiers in Oncology·Simon K B SpohnConstantinos Zamboglou
Aug 6, 2019·Seminars in Oncology·Rosa FontiSilvana Del Vecchio
Nov 20, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Constantinos ZamboglouAnca-Ligia Grosu
Jan 6, 2021·Communications Biology·Marcin PaczkowskiPavitra Kannan
Mar 14, 2021·Scientific Reports·Constantinos ZamboglouSimon K B Spohn
Jan 6, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jeremie CalaisNicholas G Nickols
Nov 1, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Dejan KostyszynConstantinos Zamboglou
Jun 1, 2021·Frontiers in Oncology·Simon K B SpohnConstantinos Zamboglou
Jul 15, 2021·Nuklearmedizin. Nuclear Medicine·Constantin LapaUNKNOWN “Arbeitsgemeinschaft Nuklearmedizin und Strahlentherapie der DEGRO und DGN”
Jul 15, 2021·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Constantin LapaUNKNOWN Arbeitsgemeinschaft Nuklearmedizin und Strahlentherapie der DEGRO und DGN
Aug 29, 2021·Pharmaceuticals·Ute Hennrich, Matthias Eder
Nov 14, 2021·Acta Oncologica·Anna KuismaHeikki Minn